Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in
Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional …

The biology and behavior of adults differ substantially from those of developing animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus …

Cells under stress must adjust their physiology, metabolism, and architecture to adapt to the
new conditions. Most importantly, they must down-regulate general gene expression, but at …

Water is critical for the survival of most cells and organisms. Remarkably, a small number of
multicellular animals are able to survive nearly complete drying. The phenomenon of …

Abstract Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing
pancreatic β-cells are destroyed. Intestinal helminths can cause asymptomatic chronic and …

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …

Having multiple rounds of translation of the same mRNA creates dynamic complexities
along with opportunities for regulation related to ribosome pausing and stalling at specific …

Cells must appropriately sense and integrate multiple metabolic resources to commit to
proliferation. Here, we report that S. cerevisiae cells regulate carbon and nitrogen metabolic …