Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss
Understanding prostate cancer onset and progression in order to rationally treat this disease
has been critically limited by a dire lack of relevant pre-clinical animal models. We have …
has been critically limited by a dire lack of relevant pre-clinical animal models. We have …
[HTML][HTML] Protocol for investigating tertiary lymphoid structures in human and murine fixed tissue sections using Opal™-TSA multiplex immunohistochemistry
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates that can develop within
or adjacent to tumors, but protocols that can accurately identify and characterize TLSs are …
or adjacent to tumors, but protocols that can accurately identify and characterize TLSs are …
Spatially Characterizing the Immune Contexture in Mouse Tissue Using Multiplex Immunohistochemistry
Multiplex immunohistochemistry (mIHC) facilitates the simultaneous detection of various
immune cell markers on a single tissue section. Here, we describe a protocol for an mIHC …
immune cell markers on a single tissue section. Here, we describe a protocol for an mIHC …
The organization of microenvironments by eosinophil granulocytes and macrophages during local inflammation
A Kolbinger - 2023 - publikationen.ub.uni-frankfurt.de
Inflammation is a crucial host defense mechanism activated in response to injury or
infection. Its primary goal is to eliminate the source of the disturbance, repair the damaged …
infection. Its primary goal is to eliminate the source of the disturbance, repair the damaged …