IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Effector CD8+ T cells are typically thought to be a homogenous group of cytotoxic cells that
produce interferon-(IFN) γ. However, recent findings have challenged this notion because …

Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …

CD8+ T cell exhaustion is a major barrier to current anti-cancer immunotherapies. Despite
this, the developmental biology of exhausted CD8+ T cells (Tex) remains poorly defined …

TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this
Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the …

Patients who receive chimeric antigen receptor (CAR)–T cells that are enriched in memory T
cells exhibit better disease control as a result of increased expansion and persistence of the …

Recent progress in cancer immunotherapy emphasizes the importance of understanding
immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to …

Tissue-resident memory T (Trm) cells contribute to local immune protection in non-lymphoid
tissues such as skin and mucosa, but little is known about their transcriptional regulation …

The immune system has tailored its effector functions to optimally respond to distinct species
of microbes. Based on emerging knowledge on the different effector T-cell and innate …

Adaptive immune responses are tailored to different types of pathogens through
differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T …