Different etiologies such as drug toxicity, acute viral hepatitis B, or acetaminophen poisoning
can cause acute liver injury or even acute liver failure (ALF). Excessive cell death of …

Kupffer cells reside within the liver sinusoid and serve as gatekeepers. They produce pro-
and anti-inflammatory cytokines and other biologically important molecules upon the …

The liver has a remarkable capacity to regenerate after injury; yet, the role of macrophages
(MF) in this process remains controversial mainly due to difficulties in distinguishing …

Background & Aim Following acetaminophen (APAP) overdose, acute liver injury (ALI) can
occur in patients that present too late for N-acetylcysteine treatment, potentially leading to …

Acetaminophen (APAP) overdose can result in serious liver injury and potentially death.
Toxicity is dependent on metabolism of APAP to a reactive metabolite initiating a cascade of …

Hepatocytes and their in vitro models are essential tools for preclinical screening studies for
drugs that affect the liver. Most of the current models primarily focus on hepatocytes alone …

The metabolic intermediate of acetaminophen (APAP) can cause severe hepatocyte
necrosis, which triggers aberrant immune activation of liver non-parenchymal cells (NPC) …

Background: The liver has a number of functions in innate immunity. These functions
predispose the liver to innate immune-mediated liver injury when inflammation goes …

Necrosis is an overarching term that describes cell death modalities caused by (extreme)
adverse conditions in which cells lose structural integrity. A guaranteed consequence of …

Although the detrimental effects of diabetes mellitus/hyperglycemia have been observed in
many liver disease models, the function and mechanism of hyperglycemia regulating liver …