The discovery of penicillin by Sir Alexander Fleming in 1928 provided us with access to a
new class of compounds useful at fighting bacterial infections: antibiotics. Ever since, a …

Bacterial resistance to therapeutical drugs has been a serious issue over the last decades.
In fact, the quick development of resistance mechanisms by the microorganisms has been …

A total synthesis of tiacumicin B, a natural macrolide whose remarkable antibiotic properties
are used to treat severe intestinal infections, is reported. The strategy is in part based on the …

Abstract Fidaxomicin (1, lipiarmycin A3, clostomicin B1, tiacumicin B) constitutes a
glycosylated 18‐membered macrolactone and is a natural product isolated from various soil …

PdII and CuI cooperate in catalyzing the alkynes hydrocarbation of allenes (AHA) giving (E)-
1, 3-enynes with high yields, atom economy, and high regio-/stereoselectivities. We devised …

We give a full account of the total synthesis of tiacumicin B (Tcn‐B), a natural glycosylated
macrolide with remarkable antibiotic properties. Our strategy is based on our experience …

Abstract Fidaxomicin (1, tiacumicin B, lipiarmycin A3) is a marketed antibiotic that is used in
the treatment of Clostridium difficile infections. Based on the analysis of a cryo‐EM structure …

Efficient approaches that enable the synthesis of analogs of natural product antibiotics are
needed to keep up with the emergence of multiply-resistant strains of pathogenic organisms …

In carbohydrate chemistry, the stereoselective synthesis of 1, 2-cis-glycosides remains a
formidable challenge. This complexity is comparable to the synthesis of 1, 2-cis-β-D …

Physicochemical and thermodynamic characterizations of fidaxomicin crystals were
investigated to develop novel formulations for efficient therapeutic activity. The pKa of …