Reperfusion therapy in acute ischemic stroke: dawn of a new era?
Following the success of recent endovascular trials, endovascular therapy has emerged as
an exciting addition to the arsenal of clinical management of patients with acute ischemic …
an exciting addition to the arsenal of clinical management of patients with acute ischemic …
A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion
L Shi, M Rocha, RK Leak, J Zhao… - Journal of Cerebral …, 2018 - journals.sagepub.com
Recent advances in stroke reperfusion therapies have led to remarkable improvement in
clinical outcomes, but many patients remain severely disabled, due in part to the lack of …
clinical outcomes, but many patients remain severely disabled, due in part to the lack of …
Fast versus slow progressors of infarct growth in large vessel occlusion stroke: clinical and research implications
M Rocha, TG Jovin - Stroke, 2017 - Am Heart Assoc
2622 Stroke September 2017 cerebral edema and symptomatic intracranial hemorrhage,
which defines a malignant profile. 27 Because such patients have lowest rates of favorable …
which defines a malignant profile. 27 Because such patients have lowest rates of favorable …
Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain
DJ Cook, L Teves, M Tymianski - Nature, 2012 - nature.com
All attempts at treating strokes by pharmacologically reducing the human brain's
vulnerability to ischaemia have failed, leaving stroke as a leading cause of death, disability …
vulnerability to ischaemia have failed, leaving stroke as a leading cause of death, disability …
Can restoring incomplete microcirculatory reperfusion improve stroke outcome after thrombolysis?
T Dalkara, EM Arsava - Journal of Cerebral Blood Flow & …, 2012 - journals.sagepub.com
Substantial experimental data and recent clinical evidence suggesting that tissue
reperfusion is a better predictor of outcome after thrombolysis than recanalization …
reperfusion is a better predictor of outcome after thrombolysis than recanalization …
Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study
K Yu, XF Chen, J Guo, S Wang, XT Huang, Y Guo… - BMC medicine, 2023 - Springer
Background Stroke is a major cause of mortality and long-term disability worldwide. Whether
the associations between brain imaging-derived phenotypes (IDPs) and stroke are causal is …
the associations between brain imaging-derived phenotypes (IDPs) and stroke are causal is …
[HTML][HTML] Targeting ischemic penumbra: part I-from pathophysiology to therapeutic strategy
S Liu, SR Levine, HR Winn - Journal of experimental stroke & …, 2010 - ncbi.nlm.nih.gov
Penumbra is the viable tissue around the irreversibly damaged ischemic core. The purpose
of acute stroke treatment is to salvage penumbral tissue and to improve brain function …
of acute stroke treatment is to salvage penumbral tissue and to improve brain function …
[HTML][HTML] TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner
TP53-induced glycolysis and apoptosis regulator (TIGAR) alleviates oxidative stress and
protects against ischemic neuronal injury by shifting glucose metabolism into the pentose …
protects against ischemic neuronal injury by shifting glucose metabolism into the pentose …
Hyperperfusion profiles after recanalization differentially associate with outcomes in a rat ischemic stroke model
BAA Franx, GAF Van Tilborg, A Taha… - Journal of Cerebral …, 2024 - journals.sagepub.com
Futile recanalization hampers prognoses of ischemic stroke after successful mechanical
thrombectomy, hypothetically through post-recanalization perfusion deficits, onset-to-groin …
thrombectomy, hypothetically through post-recanalization perfusion deficits, onset-to-groin …
Notch-induced rat and human bone marrow stromal cell grafts reduce ischemic cell loss and ameliorate behavioral deficits in chronic stroke animals
T Yasuhara, N Matsukawa, K Hara, M Maki… - Stem cells and …, 2009 - liebertpub.com
Gene transfection with Notch 1 intracellular domain and subsequent growth factor treatment
stimulate neuron-like differentiation of bone marrow stromal cells (BMSCs). Here, we …
stimulate neuron-like differentiation of bone marrow stromal cells (BMSCs). Here, we …