Changes of the electrical charges across the surface cell membrane are absolutely
necessary to maintain cellular homeostasis in physiological as well as in pathological …

The human ether-à-go-go related gene (HERG) encodes the alpha subunit of Kv11. 1, which
is a voltage-gated K+ channel protein mainly expressed in heart and brain tissue. HERG …

Potassium ion channels are critical in the regulation of cell motility. The acquisition of cell
motility is an essential parameter of cancer metastasis. However, the role of K+ channels in …

It has long been known that the resting potential of tumor cells is depolarized relative to their
normal counterparts. More recent work has provided evidence that resting potential is not …

Simple Summary Glioblastoma is a rapidly progressing brain cancer that is very difficult to
treat. Given that many aspects of cell and tissue behavior are controlled by electric signaling …

Cancer treatment requires the participation of multiple targets/pathways, and single
approach is hard to effectively curb the proliferation and metastasis of carcinoma cells. In …

Cancer is a pernicious and pressing medical problem; moreover, it is a failure of
multicellular morphogenesis that sheds much light on evolutionary developmental biology …

Potassium ion (K+) channels have been recently found to play a critical role in cancer
biology. Despite that pharmacologic manipulation of ion channels is recognized as an …

The prevention of metastasis is a central goal of cancer therapy. Caveolin-1 (Cav-1) is a
structural membrane and scaffolding protein shown to be a key regulator of late-stage breast …

Background The human ether a-go-go-related gene 1 (HERG1) is involved in tumor
progression; however, its role in esophageal squamous cell carcinoma (ESCC) is not well …