Meningococcal disease remains an important cause of morbidity and death worldwide
despite the development and increasing implementation of effective vaccines. Elimination of …

The DNA base modification N 6-methyladenine (m6A) is involved in many pathways related
to the survival of bacteria and their interactions with hosts. Nanopore sequencing offers a …

Nontypeable Haemophilus influenzae (NTHi) exclusively colonize and infect humans and
are critical to the pathogenesis of chronic obstructive pulmonary disease (COPD). In vitro …

Neisseria meningitidis is commensal of the human pharynx and occasionally invades the
host, causing the life-threatening illness invasive meningococcal disease. The …

Background Reverse vaccinology accelerates the discovery of potential vaccine candidates
(PVCs) prior to experimental validation. Current programs typically use one bacterial …

Neisseria meningitidis is the most common cause of bacterial meningitis in children and
young adults worldwide. A 4-component vaccine against N. meningitidis serogroup B …

Malaria parasites have small extremely AT-rich genomes: microsatellite repeats (1–9 bp)
comprise 11% of the genome and genetic variation in natural populations is dominated by …

Background Meningococcal colonization is a prerequisite for transmission and disease, but
the bacterium only very infrequently causes disease while asymptomatic carriage is …

Pathogenic Neisseria are responsible for significantly higher levels of morbidity and
mortality than their commensal relatives despite having similar genetic contents. Neisseria …

Some members of the physiological human microbiome occasionally cause life-threatening
disease even in immunocompetent individuals. A prime example of such a commensal …