[HTML][HTML] Recent developments in synthetic chemistry and biological activities of pyrazole derivatives

M Faisal, A Saeed, S Hussain, P Dar… - Journal of Chemical …, 2019 - Springer
Pyrazole, a five-membered heterocycle containing two nitrogen atoms, is extensively found
as a core framework in a huge library of heterocyclic compounds that envelops promising …

Current progress on antioxidants incorporating the pyrazole core

VLM Silva, J Elguero, AMS Silva - European journal of medicinal chemistry, 2018 - Elsevier
The search of new antioxidants, as drugs candidates, is an active field of medicinal
chemistry. The synthesis of compounds with antioxidant potential has increased in recent …

Recent progress in anticancer agents incorporating pyrazole scaffold

S Mor, M Khatri, S Sindhu - Mini Reviews in Medicinal …, 2022 - ingentaconnect.com
The search for new anticancer agents is considered a dynamic field of medicinal chemistry.
In recent years, the synthesis of compounds with anticancer potential has increased and a …

[PDF][PDF] A review on Pyrazole derivatives of pharmacological potential

A Jamwal, A Javed, V Bhardwaj - J. Pharm. BioSci, 2013 - speronline.com
Pyrazole is five membered heterocyclic rings which is versatile lead compound for designing
potent bioactive agent. The interesting groups of this compound has diverse biological …

The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review.

J Dwivedi, S Sharma, S Jain, A Singh - Mini Reviews in Medicinal …, 2018 - europepmc.org
Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for
combinatorial as well as medicinal chemistry. This review presents a detailed overview on …

[HTML][HTML] Potential anti-inflammatory effect of LQFM-021 in carrageenan-induced inflammation: the role of nitric oxide

IF Florentino, DPB Silva, DM Silva, CS Cardoso… - Nitric Oxide, 2017 - Elsevier
The pyrazole compound LQFM-021 exhibits vasorelaxant, antinociceptive and anti-
inflammatory activities. Furthermore, it has low toxicity, indicating that this compound may be …

Analgesic and Antipyretic Activities of Ethyl Acetate Fraction Tablet of Andrographis paniculata in Animal Models

H Ilmi, IR Pamungkas, L Tumewu… - Evidence‐Based …, 2021 - Wiley Online Library
Objectives. To determine the analgesic and antipyretic activities of a tablet derived from
Andrographis paniculata ethyl acetate fraction (AS201‐01) in animal models. Methods. The …

Antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole. A Celecoxib structural analog in models of pathological pain

SM Oliveira, CR Silva, AP Wentz, GR Paim… - Pharmacology …, 2014 - Elsevier
Pain is the most common complaint in the medical field and the identification of novel
compounds that can effectively treat painful states without causing side effects remains a …

[HTML][HTML] An Unusual Rearrangement of Pyrazole Nitrene and Coarctate Ring-Opening/Recyclization Cascade: Formal CH–Acetoxylation and Azide/Amine Conversion …

E Chugunova, AS Gazizov, D Islamov, V Matveeva… - Molecules, 2023 - mdpi.com
We report an unusual transformation where the transient formation of a nitrene moiety
initiates a sequence of steps leading to remote oxidative C–H functionalization (R–CH3 to R …

Design, synthesis of tri‐substituted pyrazole derivatives as promising antimicrobial agents and investigation of structure activity relationships

GM Reddy, JR Garcia, G Yuvaraja… - Journal of …, 2020 - Wiley Online Library
The major diseases spread in the environment only because of microbes. Even, intensive
care units in the hospitals are polluted by microorganisms, particularly, Gram‐positive …