Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
GDF15 linked to maternal risk of nausea and vomiting during pregnancy
M Fejzo, N Rocha, I Cimino, SM Lockhart, CJ Petry… - Nature, 2024 - nature.com
GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting
of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full …
of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
All around suboptimal health—a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and …
First two decades of the twenty-first century are characterised by epidemics of non-
communicable diseases such as many hundreds of millions of patients diagnosed with …
communicable diseases such as many hundreds of millions of patients diagnosed with …
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
A general approach for haplotype phasing across the full spectrum of relatedness
Many existing cohorts contain a range of relatedness between genotyped individuals, either
by design or by chance. Haplotype estimation in such cohorts is a central step in many …
by design or by chance. Haplotype estimation in such cohorts is a central step in many …
Application of high-dimensional feature selection: evaluation for genomic prediction in man
ML Bermingham, R Pong-Wong, A Spiliopoulou… - Scientific reports, 2015 - nature.com
In this study, we investigated the effect of five feature selection approaches on the
performance of a mixed model (G-BLUP) and a Bayesian (Bayes C) prediction method. We …
performance of a mixed model (G-BLUP) and a Bayesian (Bayes C) prediction method. We …
Glycans are a novel biomarker of chronological and biological ages
Fine structural details of glycans attached to the conserved N-glycosylation site significantly
not only affect function of individual immunoglobulin G (IgG) molecules but also mediate …
not only affect function of individual immunoglobulin G (IgG) molecules but also mediate …
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment
A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …
Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data
Inbreeding depression, which refers to reduced fitness among offspring of related parents,
has traditionally been studied using pedigrees. In practice, pedigree information is difficult to …
has traditionally been studied using pedigrees. In practice, pedigree information is difficult to …