Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain
bioenergetic levels related to cellular functions. This absence of proper adaptation can be …

Metabolic reprogramming is one of the hallmarks of tumors. Alterations of cellular
metabolism not only contribute to tumor development, but also mediate the resistance of …

The clinical presentation of triple-negative breast cancer signifies a pathophysiological
trajectory characterized by an aggressive nature. To satisfy the rapid tumor cell proliferation …

Simple Summary Cancer stem cells (CSCs) have been shown to be the main cause of
therapy resistance and cancer recurrence. An analysis of their biological properties has …

Cancer stem cells (CSCs) are the most important cause of cancer treatment failure.
Traditional cancer treatments, such as chemotherapy and radiotherapy, damage healthy …

Cancer cells rewire metabolic processes to adapt to the nutrient-and oxygen-deprived
tumour microenvironment, thereby promoting their proliferation and metastasis. Previous …

Simple Summary Cancer stem cells (CSCs) are an engine of tumor progression and a
source of tumor therapy resistance and regrowth after treatment. Modern conventional …

In patients with cancer with metastatic disease, the rate of complete tumor response to
systemic therapies is low, and residual lesions persist in the majority of patients due to early …

Cellular metabolic reprogramming is an important feature of malignant tumors. Metabolic
reprogramming causes changes in the levels or types of specific metabolites inside and …

Flavopiridol is a flavone synthesized from the natural product rohitukine, which is derived
from an Indian medicinal plant, namely Dysoxylum binectariferum Hiern. A deeper …