▪ Abstract The ability of pathogens to obtain iron from transferrins, ferritin, hemoglobin, and
other iron-containing proteins of their host is central to whether they live or die. To combat …

▪ Abstract Modern chemotherapy has played a major role in our control of tuberculosis. Yet
tuberculosis still remains a leading infectious disease worldwide, largely owing to …

Sigma factors provide promoter recognition specificity to RNA polymerase holoenzyme,
contribute to DNA strand separation, and then dissociate from the core enzyme following …

In previously published work, we identified three Mycobacterium tuberculosis sigma (σ)
factor genes responding to heat shock (sigB, sigE and sigH). Two of them (sigB and sigE) …

The ability of Mycobacterium tuberculosis to adapt to different environments in the infected
host is essential for its pathogenicity. Consequently, this organism must be able to modulate …

Diphtheria toxin (DT) is an extracellular protein of Corynebacterium diphtheriae that inhibits
protein synthesis and kills susceptible cells. The gene that encodes DT (tox) is present in …

In this work, we characterize genes in Mycobacterium tuberculosis that are regulated by
IdeR (i ron‐de pendent r egulator), an iron‐responsive DNA‐binding protein of the DtxR …

Tuberculosis remains a worldwide threat despite the availability of the BCG vaccine and
antibiotic treatment. It is estimated that its etiologic agent, Mycobacterium tuberculosis …

Summary The Staphylococcus aureus DtxR‐like protein, MntR, controls expression of the
mntABC and mntH genes, which encode putative manganese transporters. Mutation of …

Mycobacterium tuberculosis is a remarkable pathogen capable of adapting and surviving in
various harsh conditions. Correct gene expression regulation is essential for the success of …