[HTML][HTML] Current strategies to determine antifungal and antimicrobial activity of natural compounds

ES Armengol, M Harmanci, F Laffleur - Microbiological Research, 2021 - Elsevier
Fungal and microbial infections are increasingly common diseases affecting not only
humans, but also animals. Despite the fact that there are wide ranges of antifungal drugs …

[HTML][HTML] Pre-clinical tools for predicting drug efficacy in treatment of tuberculosis

H Margaryan, DD Evangelopoulos, L Muraro Wildner… - Microorganisms, 2022 - mdpi.com
Combination therapy has, to some extent, been successful in limiting the emergence of drug-
resistant tuberculosis. Drug combinations achieve this advantage by simultaneously acting …

Repurposing artemisinin as an anti-mycobacterial agent in synergy with rifampicin

YS Patel, N Mistry, S Mehra - Tuberculosis, 2019 - Elsevier
The current anti-TB treatment consists of a prolonged multi-drug therapy. Interventional
strategies are required to reduce the chemotherapeutic load. In this regard, we have …

[HTML][HTML] Efficacy of true cinnamon (Cinnamomum verum) leaf essential oil as a therapeutic alternative for Candida biofilm infections

GK Wijesinghe, TR de Oliveira, FC Maia… - Iranian journal of …, 2021 - ncbi.nlm.nih.gov
Objective (s): The essential oil (EO) extracted from Cinnamomum verum leaves has been
used as an antimicrobial agent for centuries. But its antifungal and antibiofilm efficacy is still …

[HTML][HTML] Unraveling antibiotic resistance mechanisms in Mycobacterium abscessus: the potential role of efflux pumps

SE Mudde, JA Schildkraut, NC Ammerman… - Journal of Global …, 2022 - Elsevier
Objectives Mycobacterium abscessus is an opportunistic respiratory pathogen in patients
with underlying lung disease. It is infamously known for its low treatment success rates …

Higher Dosing of Rifamycins Does Not Increase Activity against Mycobacterium tuberculosis in the Hollow-Fiber Infection Model

ED Pieterman, S van den Berg… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Improvements in the translational value of preclinical models can allow more-successful and
more-focused research on shortening the duration of tuberculosis treatment. Although the …

Zno nanoparticles and rifampicin synergistically damage the membrane of mycobacteria

N Mistry, R Bandyopadhyaya… - ACS Applied Nano …, 2020 - ACS Publications
The emergence of drug resistance in tuberculosis requires alternative strategies to combat
the resistance. To this end, we have synthesized zinc oxide nanoparticles (ZnO NPs) of 11 …

[HTML][HTML] Rediscovering Medicinal Amazonian Aromatic Plants: Piper carpunya (Piperaceae) Essential Oil as Paradigmatic Study

JL Ballesteros, M Tacchini, A Spagnoletti… - Evidence-Based …, 2019 - hindawi.com
Piper carpunya Ruiz & Pav.(Piperaceae) is a perennial aromatic shrub of Amazonian area of
Ecuador and Peru, belonging to the ethnomedicine of these countries. The traditional …

Bactericidal effect of pyridine-2-thiol 1-oxide sodium salt and its complex with iron against resistant clinical isolates of Mycobacterium tuberculosis

DL Campos, I Machado, CM Ribeiro… - The Journal of …, 2020 - nature.com
The objective of this study was to determine the activity of pyridine-2-thiol 1-oxide sodium
salt (Na mpo) and its complex with iron [Fe (mpo) 3] against Mycobacterium tuberculosis …

[HTML][HTML] The potential role of drug transporters and amikacin modifying enzymes in M. avium

JA Schildkraut, JPM Coolen, C Ruesen… - Journal of Global …, 2023 - Elsevier
Objectives Mycobacterium avium (M. avium) complex bacteria cause opportunistic infections
in humans. Treatment yields cure rates of 60% and consists of a macrolide, a rifamycin, and …