COVID-19 and male reproductive system: pathogenic features and possible mechanisms

A Ardestani Zadeh, D Arab - Journal of molecular histology, 2021 - Springer
Multiorgan dysfunction is the main characteristic of severe COVID-19 patients and the
involvement of male reproductive system may occur among these patients. Although there is …

Role of NLRP3 Inflammasome in post-spinal-cord-injury anxiety and depression: molecular mechanisms and therapeutic implications

T Mokhtari, K Uludag - ACS Chemical Neuroscience, 2023 - ACS Publications
The majority of research on the long-term effects of spinal cord injury (SCI) has primarily
focused on neuropathic pain (NP), psychological issues, and sensorimotor impairments …

Subventricular zone-derived extracellular vesicles promote functional recovery in rat model of spinal cord injury by inhibition of NLRP3 inflammasome complex …

I Mohammed, S Ijaz, T Mokhtari, M Gholaminejhad… - Metabolic brain …, 2020 - Springer
Spinal cord injury (SCI) is the destruction of spinal cord motor and sensory resulted from an
attack on the spinal cord, which can cause significant physiological damage. The …

NLRP3 inflammasome: A new pharmacological target for reducing testicular damage associated with varicocele

P Antonuccio, AG Micali, C Romeo, J Freni… - International Journal of …, 2021 - mdpi.com
Many bioactive natural compounds are being increasingly used for therapeutics and
nutraceutical applications to counteract male infertility, particularly varicocele. The roles of …

All-trans retinoic acid–preconditioned mesenchymal stem cells improve motor function and alleviate tissue damage after spinal cord injury by inhibition of HMGB1/NF …

M Gholaminejhad, SB Jameie, M Abdi… - Journal of Molecular …, 2022 - Springer
Spinal cord injury (SCI) is a significant public health issue that imposes numerous burdens
on patients and society. Uncontrolled excessive inflammation in the second pathological …

The role of NLRP3 inflammasome activation and oxidative stress in varicocele-mediated male hypofertility

G Poli, C Fabi, C Sugoni, MM Bellet… - International Journal of …, 2022 - mdpi.com
Varicocele (VC) is the most common abnormality identified in men evaluated for hypofertility.
Increased levels of reactive oxygen species (ROS) and reduced antioxidants concentrations …

Modulating pro-inflammatory cytokines, tissue damage magnitude, and motor deficit in spinal cord injury with subventricular zone-derived extracellular vesicles

S Ijaz, I Mohammed, M Gholaminejhad… - Journal of Molecular …, 2020 - Springer
Background The upregulation of TNF-α, IL-1β, IL-18, and IL-6 exacerbates the spinal cord
injury by amplifying the neuroinflammation. Impeding the release and activation of these …

Protective role of eugenol against diabetes‐induced oxidative stress, DNA damage, and apoptosis in rat testes

SR Chilukoti, C Sahu, G Jena - Journal of Biochemical and …, 2024 - Wiley Online Library
Diabetes mellitus, a metabolic disorder alters gonadal development and spermatogenesis,
reactive oxygen species production, DNA damage, and apoptosis, which subsequently lead …

Involvement of NF-κB/NLRP3 axis in the progression of aseptic loosening of total joint arthroplasties: a review of molecular mechanisms

M Qoreishi, M Panahi, O Dorodi, N Ghanbari… - Naunyn-Schmiedeberg's …, 2022 - Springer
Particulate wear debris can trigger pro-inflammatory bone resorption and result in aseptic
loosening. This complication remains major postoperative discomforts and complications for …

[HTML][HTML] Presence of the NLRP3 inflammasome components in semen of varicocele patients

M Baazm, AA Ghafarizadeh, ARN Kamran… - … journal of fertility & …, 2020 - ncbi.nlm.nih.gov
Background Varicocele is a common cause of male infertility with multifactorial etiology.
Inflammation is a characteristic pathological event that occurs in the testis tissue following …