Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …

High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …

The serum metabolome contains a plethora of biomarkers and causative agents of various
diseases, some of which are endogenously produced and some that have been taken up …

Few studies have explored the impact of rare variants (minor allele frequency< 1%) on
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …

The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …

Background: Blood lipids are established risk factors for myocardial infarction (MI), but
uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating …

Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …

Genome-wide association studies have identified numerous loci linked with complex
diseases, for which the molecular mechanisms remain largely unclear. Comprehensive …

Branched-chain amino acids (BCAAs) are important nutrient signals that have direct and
indirect effects. Frequently, BCAAs have been reported to mediate antiobesity effects …

Metabolomics is becoming common in epidemiology due to recent developments in
quantitative profiling technologies and appealing results from their applications for …