Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …

Male factor infertility is increasing in developed countries, and several factors linked to
lifestyle have been shown to negatively affect spermatogenesis. Sertoli cells are pivotal to …

Diabetes mellitus (DM) is one of the greatest public health threats in modern societies.
Although during a few years it was suggested that DM had no significant effect in male …

Hormonal regulation is essential to spermatogenesis. Sertoli cells (SCs) have functions that
reach far beyond the physical support of germ cells, as they are responsible for creating the …

Otto Warburg observed that cancerous cells prefer fermentative instead of oxidative
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …

Diabetes mellitus is a metabolic disorder that may arise from diet habits and is growing to
epidemic proportions. Young male diabetic patients present high infertility/subfertility …

Male fertility is declining in developed countries, as well as in developing countries. External
factors linked to lifestyle, such as eating disorders, negatively affect spermatogenesis, both …

Blood testis barrier (BTB) is one of the tightest blood-barriers controlling the entry of
substances into the intratubular fluid. Diabetes Mellitus (DM) is an epidemic metabolic …

This study assessed the effect of quercetin (QE) on cadmium chloride (CdCl 2)− induced
testicular toxicity, as well as the effect of withdrawal of CdCl 2 treatment on same. Thirty male …

Follicle-stimulating hormone signaling is essential for the initiation and early stages of
spermatogenesis. Follicle-stimulating hormone receptor is exclusively expressed in Sertoli …