Motivation Flow cytometry (FCM) and transcription profiling are the two widely used assays
in translational immunology research. However, there is no data integration pipeline for …

This thesis presents several methods for analyzing longitudinal clinical trial data, and
applies the methods in a data analysis of the INSIGHT study. Chapter 1 summarizes the …

Using penalized profiled log-likelihood and penalized limited profiled log-likelihood,
respectively, together with the weighted ridge penalized term, we offer a method in this study …