Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

Background Cardiovascular disease (CVD) has been the leading cause of death worldwide
for many years. In recent years, exosomes have gained extensive attention in the …

Rationale: During the development of atherosclerosis, macrophages secrete exosomes that
regulate vascular smooth muscle cells (VSMCs); however, whether nicotine, a major …

Understanding molecular mechanisms involved in vascular aging is essential to develop
novel interventional strategies for treatment and prevention of age-related vascular …

Pulsatility seems to have a teleological role because evolutionary hierarchy favors higher
ordered animals with more complex, multichamber circulatory systems that generate higher …

Atherosclerosis, a complex chronic inflammatory disease, involves multiple alterations of
diverse cells, including endothelial cells (ECs), vascular smooth muscle cells (VSMCs) …

Vascular smooth muscle cells (SMC) possess a unique cytoplasticity, regulated by
transcriptional, translational and phenotypic transformation in response to a diverse range of …

Objective: Pathological vascular remodeling and excessive perivascular fibrosis are major
contributors to reduced vessel compliance that exacerbates cardiovascular diseases, for …

Atherosclerosis is a chronic inflammatory disease of the arterial wall caused by an
imbalance of lipid metabolism and a maladaptive inflammatory response. A variety of …

Objective: Our recent work demonstrates that PTEN (phosphatase and tensin homolog) is an
important regulator of smooth muscle cell (SMC) phenotype. SMC-specific PTEN deletion …