Malformations of cortical development (MCDs) are neurodevelopmental disorders that result
from abnormal development of the cerebral cortex in utero. MCDs place a substantial …

Autosomal recessive primary microcephaly (MCPH;“small head syndrome”) is a rare,
heterogeneous disease arising from the decreased production of neurons during brain …

Microcephaly or reduced head circumference results from a multitude of abnormal
developmental processes affecting brain growth and/or leading to brain atrophy. Autosomal …

During mammalian brain development, neural stem and progenitor cells generate the
neurons for the six-layered neocortex. The proliferative capacity of the different types of …

Primary microcephaly (MCPH), is a neurological disorder characterized by small brain size
that results in numerous developmental problems, including intellectual disability, motor and …

DNA-damaging agents and endogenous DNA damage constantly harm genome integrity.
Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in …

ASPM is a protein encoded by primary microcephaly 5 (MCPH5) and is responsible for
ensuring spindle position during mitosis and the symmetrical division of neural stem cells …

Medulloblastoma (MB) and gliomas are the most frequent high-grade brain tumors (HGBT)
in children and adulthood, respectively. The general treatment for these tumors consists in …

The lysosomal degradation pathway of macroautophagy (herein referred to as autophagy)
plays a crucial role in cellular physiology by regulating the removal of unwanted cargoes …

The Drosophila abnormal spindle (asp) gene was discovered about 40 years ago and
shown to be required for both mitotic and meiotic cell division. Subsequent studies showed …