[HTML][HTML] Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity …
Nano-structured lipid carriers containing zopiclone were prepared as a targeted drug
delivery system to convey zopiclone directly to brain via nasal route. Nano-structured lipid …
delivery system to convey zopiclone directly to brain via nasal route. Nano-structured lipid …
[HTML][HTML] Strategies for organic nanoparticles delivering CRISPR/Cas9 for cancer therapy: Challenges and breakthroughs
T Zhang, Q Lv, M Zhao, Y Liu, Q Wang, Y Chen… - Materials & Design, 2024 - Elsevier
The recent years have witnessed the rapid advancement of clustered regularly interspaced
short palindromic repeats/associated protein 9 (CRISPR/Cas9)-mediated gene editing in …
short palindromic repeats/associated protein 9 (CRISPR/Cas9)-mediated gene editing in …
[HTML][HTML] Chitosan-coated nanostructured lipid carriers for effective brain delivery of Tanshinone IIA in Parkinson's disease: interplay between nuclear factor-kappa β …
Parkinson's disease (PD) is the second most common progressive neurodegenerative
disorder associated with increased oxidative stress, the underlying vital process contributing …
disorder associated with increased oxidative stress, the underlying vital process contributing …
Sonophoresis-assisted transdermal delivery of antimigraine-loaded nanolipomers: Radio-tracking, histopathological assessment and in-vivo biodistribution study
Migraine is a disabling neurovascular polygenic disorder affecting life quality with escorted
socioeconomic encumbrances. Herein, we investigated the consolidated amalgamation of …
socioeconomic encumbrances. Herein, we investigated the consolidated amalgamation of …
[HTML][HTML] Brain targeting of zolmitriptan via transdermal terpesomes: statistical optimization and in vivo biodistribution study by 99mTc radiolabeling technique
Zolmitriptan (ZT) is a potent second generation triptan, commonly administered to alleviate
migraine attacks. ZT suffers various limitations; massive hepatic first pass metabolism, P-gp …
migraine attacks. ZT suffers various limitations; massive hepatic first pass metabolism, P-gp …
[HTML][HTML] Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for …
Duloxetine hydrochloride (DUL) is a BCS class-II antidepressant drug, acting via serotonin
and norepinephrine reuptake inhibition. Despite high oral absorption, DUL suffers limited …
and norepinephrine reuptake inhibition. Despite high oral absorption, DUL suffers limited …
[HTML][HTML] Spanlastics as a potential platform for enhancing the brain delivery of flibanserin: in vitro response-surface optimization and in vivo pharmacokinetics …
WS Alharbi, RH Hareeri, M Bazuhair, MA Alfaleh… - Pharmaceutics, 2022 - mdpi.com
Flibanserin was licensed by the United States Food and Drug Administration (FDA) as an
oral non-hormonal therapy for pre-menopausal women with inhibited sexual desire disorder …
oral non-hormonal therapy for pre-menopausal women with inhibited sexual desire disorder …
[HTML][HTML] Physico-chemical characterization of the tumour microenvironment of pancreatic ductal adenocarcinoma
E García-Gareta, A Calderón-Villalba… - European Journal of …, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy that
accounts for more than 90% of pancreatic cancer diagnoses. Our research is focused on the …
accounts for more than 90% of pancreatic cancer diagnoses. Our research is focused on the …
Investigating the potential of highly porous zopiclone-loaded 3D electrospun nanofibers for brain targeting via the intranasal route
Nanofibers (NFs) have proven to be very attractive tool as drug delivery plateform among the
different plethora of nanosystems, owing to their unique features. They exhibit two-and three …
different plethora of nanosystems, owing to their unique features. They exhibit two-and three …
[HTML][HTML] Kinetics and thermodynamics of adsorption for aromatic hydrocarbon model systems via a coagulation process with a ferric sulfate–lime softening system
DJ Venegas-García, LD Wilson - Materials, 2023 - mdpi.com
The adsorption mechanisms for model hydrocarbons, 4-nitrophenol (PNP), and naphthalene
were studied in a coagulation-based process using a ferric sulfate–lime softening system …
were studied in a coagulation-based process using a ferric sulfate–lime softening system …