Antigenic variation as a strategy to evade the host adaptive immune response has evolved
in divergent pathogens. Antigenic variation involves restricted, and often mutually exclusive …

Trypanosoma brucei is a model trypanosomatid, an important group of human, animal and
plant unicellular parasites. Understanding their complex cell architecture and life cycle is …

Survival of the African trypanosome within its mammalian hosts, and hence transmission
between hosts, relies upon antigenic variation, where stochastic changes in the composition …

Trypanosomes are eukaryotic, unicellular parasites, such as Trypanosoma brucei, which
causes sleeping sickness, and Trypanosoma cruzi, which causes Chagas disease …

We have generated a high-confidence mitochondrial proteome (MitoTag) of the
Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a …

TrypTag was a 4-year project to tag the N-and C-termini of almost all Trypanosoma brucei
proteins with a fluorescent protein and record the subcellular localisation through images …

At first glance the nucleus is a highly conserved organelle. Overall nuclear morphology, the
octagonal nuclear pore complex, the presence of peripheral heterochromatin and the …

UPF1-like helicases play roles in telomeric heterochromatin formation and X-chromosome
inactivation, and also in monogenic variant surface glycoprotein (VSG) expression via VSG …

Kinetoplastids are a highly divergent lineage of eukaryotes with unusual mechanisms for
regulating gene expression. We previously surveyed 65 putative chromatin factors in the …

African trypanosomes evade host immune clearance by antigenic variation, causing
persistent infections in humans and animals. These parasites express a homogeneous …