Background Inflammatory responses play a multiphase role in the pathogenesis of cerebral
ischemic stroke (IS). Ruxolitinib (Rux), a selective oral JAK 1/2 inhibitor, reduces …

Background and purpose Long-term disability after stroke is common yet the mechanisms of
post-stroke recovery are far from clear. It has been suggested that Ras-related C3 botulinum …

Microglial activation plays a central role in poststroke inflammation and causes secondary
neuronal damage; however, it also contributes in debris clearance and chronic recovery …

Aim To study the role of exosomes in the protective effect of cerebral ischemic
preconditioning (cerebral‐IPC) against cerebral I/R injury. Method Mouse models of cerebral …

Cholesterol is biosynthesized by all animal cells. Beyond its metabolic role in
steroidogenesis, it is enriched in the plasma membrane where it has key structural and …

Ischemic stroke can cause blood-brain barrier (BBB) injury, which worsens brain damage
induced by stroke. Abnormal expression of tight junction proteins in endothelial cells (ECs) …

Long‐term disability after stroke is common but the mechanisms of post‐stroke recovery
remain unclear. Cerebral Ras‐related C3 botulinum toxin substrate (Rac) 1 contributes to …

Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is a pro-
degenerative molecule in Wallerian degeneration, which is mainly expressed in …

Adipose-derived mesenchymal stem cells markedly attenuated brain infarct size and
improved neurological function in rats. The mechanisms for neuronal cell death have …

Brain functional impairment after stroke is common; however, the molecular mechanisms of
post-stroke recovery remain unclear. It is well-recognized that age is the most important …