Role of microRNAs in obesity-related kidney disease

M Caus, À Eritja, M Bozic - International Journal of Molecular Sciences, 2021 - mdpi.com
Obesity is a major global health problem and is associated with a significant risk of renal
function decline. Obesity-related nephropathy, as one of the complications of obesity, is …

Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice

T Huang, T Wu, Y Wu, X Li, J Tan, C Shen… - Nature …, 2023 - nature.com
Statins play an important role in the treatment of diabetic nephropathy. Increasing attention
has been given to the relationship between statins and insulin resistance, but many …

Early triggers of moderately high‐fat diet‐induced kidney damage

A Sánchez‐Navarro, MÁ Martínez‐Rojas… - Physiological …, 2021 - Wiley Online Library
Most of the obesity murine models inducing renal injury use calorie‐enriched foods, where
fat represents 60% of the total caloric supply, however, this strategy doubles the standard …

CRISPR-Cas9 mediated genome editing of Huntington's disease neurospheres

JY Han, J Seo, Y Choi, W Im, JJ Ban, JJ Sung - Molecular Biology Reports, 2023 - Springer
Background Huntington's disease (HD) is a fatal genetic disease caused by polyglutamine
aggregation encoded by an expanded CAG repeat in the huntingtin gene (HTT). In this …

DNA methylation enzymes in the kidneys of male and female BTBR ob/ob mice

BM Veloso Pereira, M Charleaux de Ponte… - Frontiers in …, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is the leading cause of the end-stage renal disease. Recent
studies have shown that epigenetic modifications contribute to alterations in gene …

Torularhodin bilosomes attenuate high-fat diet-induced chronic kidney disease in mice by regulating the TLR4/NF-κB pathway

C Wang, C Liu, W Xu, Y Cheng, Y Guo, Y Zhao, F Shen… - Food Bioscience, 2023 - Elsevier
Torularhodin is a carotenoid that exerts beneficial effects on chronic kidney disease (CKD),
which is strongly linked to a high-fat diet (HFD), however, its functional properties have not …

Genetically predicted adiponectin causally reduces the risk of chronic kidney disease, a bilateral and multivariable mendelian randomization study

R Wu, P Luo, M Luo, X Li, X Zhong, Q He… - Frontiers in …, 2022 - frontiersin.org
Background: It is not clarified whether the elevation of adiponectin is the results of kidney
damage, or the cause of kidney function injury. To explore the causal association of …

[HTML][HTML] Chronic advanced-glycation end products treatment induces TXNIP expression and epigenetic changes in glomerular podocytes in vivo and in vitro

K Thieme, BMV Pereira, KS da Silva, NT Fabre… - Life Sciences, 2021 - Elsevier
Advanced glycation end products (AGEs) play an important role in oxidative stress and
inflammation, processes implicated in the development and progression of kidney …

Epigenetic regulation of chronic kidney disease development following prenatal maternal stress

V Sharma, S Singh, J Maini, V Srivastava - Epigenetics in Organ Specific …, 2023 - Elsevier
The incidence of chronic kidney disease (CKD) is expanding worldwide and becoming a
major global health burden irrespective of age. Early development life exposure is known to …