The current understanding and potential therapeutic options to combat COVID-19

V Pooladanda, S Thatikonda, C Godugu - Life sciences, 2020 - Elsevier
The ongoing wreaking global outbreak of the novel human beta coronavirus (CoV)
pathogen was presumed to be from a seafood wholesale market in Wuhan, China, belongs …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

An in-silico evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets

SK Sinha, A Shakya, SK Prasad, S Singh… - Journal of …, 2021 - Taylor & Francis
Abstract The Public Health Emergency of International Concern declared the widespread
outbreak of SARS-CoV-2 as a global pandemic emergency, which has resulted in 1,773,086 …

Saponins: research progress and their potential role in the post-COVID-19 pandemic era

D Mieres-Castro, F Mora-Poblete - Pharmaceutics, 2023 - mdpi.com
In the post-COVID-19 pandemic era, the new global situation and the limited therapeutic
management of the disease make it necessary to take urgent measures in more effective …

Use of natural compounds as a potential therapeutic agent against COVID-19

S Wahab, I Ahmad, S Irfan, MH Baig… - Current …, 2021 - ingentaconnect.com
The current 2019-nCoV outbreak is becoming extremely harmful and has affected the whole
world. Its control is challenging because there is no effective vaccine or drug available for …

Phosphate derivatives of 3-carboxyacylbetulin: Synthesis, in vitro anti-HIV and molecular docking study

K Marciniec, E Chrobak, A Dąbrowska, E Bębenek… - Biomolecules, 2020 - mdpi.com
Lupane-type pentacyclic triterpenes such as betulin and betulinic acid play an important role
in the search for new therapies that would be effective in controlling viral infections. The aim …

[HTML][HTML] Virtual screening of natural metabolites and antiviral drugs with potential inhibitory activity against 3CL-PRO and PL-PRO

N Contreras-Puentes… - Biomedical and …, 2020 - biomedpharmajournal.org
Aims: COVID-19 is a global pandemic that has affected around 186 countries in the world,
related to clinical signs as fever, cough and pneumonia. The disease is caused by SARS …

Microfluidic Diffusion Sizing Applied to the Study of Natural Products and Extracts That Modulate the SARS-CoV-2 Spike RBD/ACE2 Interaction

J Fauquet, J Carette, P Duez, J Zhang, A Nachtergael - Molecules, 2023 - mdpi.com
The interaction between SARS-CoV-2 spike RBD and ACE2 proteins is a crucial step for
host cell infection by the virus. Without it, the entire virion entrance mechanism is …

Molecular dynamics and docking studies on potentially active natural phytochemicals for targeting SARS-CoV-2 main protease

S Karakkadparambil Sankaran… - Journal of Biomolecular …, 2023 - Taylor & Francis
In the present study, we screened eighty seven novel phytochemical compounds from four
popular herbs, such as, Aegle Marmelos, Coleus Amboinicus, Aerva Lanata and Biophytum …

Insights on Various Antiviral Drugs for Treating Patients with COVID-19

UK De, YS Malik, K Dhama, B Ganesh… - Advances in Antiviral …, 2024 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the cause of the
first pandemic of the twenty-first century, which began in Hubei Province, China, in late …