T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …

Antigen-presenting cells contain a specialized late endocytic compartment, MIIC (major
histocompatibility complex [MHC] class II-enriched compartment), that harbors newly …

Radiotherapy is one of the most successful cancer therapies. Here the effect of irradiation on
antigen presentation by MHC class I molecules was studied. Cell surface expression of …

Association of major histocompatibility complex (MHC) class II molecules with peptides
occurs in a series of endocytic vacuoles, termed MHC class II-enriched compartments …

Adaptation of the endoplasmic reticulum (ER) pathway for MHC class I (MHC-I) presentation
in dendritic cells enables cross-presentation of peptides derived from phagocytosed …

Interleukin 10 (IL-10) and viral IL-10 (v-IL-10) strongly reduced antigen-specific proliferation
of human T cells and CD4+ T cell clones when monocytes were used as antigen-presenting …

Exosomes are 60–100-nm membrane vesicles that are secreted into the extracellular milieu
as a consequence of multivesicular body fusion with the plasma membrane. Here we …

Presentation of antigenic peptides by MHC class II molecules to CD4+ T cells is critical to the
generation of antitumor immunity. In an attempt to enhance MHC class II antigen processing …

MHC class II (MHC-II) molecules are critical in the control of many immune responses. They
are also involved in most autoimmune diseases and other pathologies. Here, we describe …