[HTML][HTML] Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses
LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …
shown the therapeutic potential effect of MSC or their derived products. However, the …
[HTML][HTML] Exosome theranostics: biology and translational medicine
C He, S Zheng, Y Luo, B Wang - Theranostics, 2018 - ncbi.nlm.nih.gov
Exosomes are common membrane-bound nanovesicles that contain diverse biomolecules,
such as lipids, proteins, and nucleic acids. Exosomes are derived from cells through …
such as lipids, proteins, and nucleic acids. Exosomes are derived from cells through …
Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice
J Sanz-Ros, N Romero-García, C Mas-Bargues… - Science …, 2022 - science.org
Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to
delay the degenerative changes associated with aging and frailty are particularly interesting …
delay the degenerative changes associated with aging and frailty are particularly interesting …
[HTML][HTML] Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome
CR Harrell, C Fellabaum, N Jovicic, V Djonov… - Cells, 2019 - mdpi.com
Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …
[HTML][HTML] Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine
FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …
their capacity for local engrafting and differentiating into multiple tissue types. However …
The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine
Abstract Mesenchymal Stem Cells (MSCs) have been shown to be a promising candidate for
cell-based therapy. The therapeutic potential of MSCs, towards tissue repair and wound …
cell-based therapy. The therapeutic potential of MSCs, towards tissue repair and wound …
Effect of the microenvironment on mesenchymal stem cell paracrine signaling: opportunities to engineer the therapeutic effect
Cues from the extracellular environment, including physical stimuli, are well known to affect
mesenchymal stem cell (MSC) properties in terms of proliferation and differentiation. Many …
mesenchymal stem cell (MSC) properties in terms of proliferation and differentiation. Many …
Advances in extracellular vesicle nanotechnology for precision theranostics
Q Wu, S Fu, H Xiao, J Du, F Cheng, S Wan… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) have increasingly been recognized as important cell surrogates
influencing many pathophysiological processes, including cellular homeostasis, cancer …
influencing many pathophysiological processes, including cellular homeostasis, cancer …
Emergence of the stem cell secretome in regenerative engineering
The secretome is defined as the set of molecules and biological factors that are secreted by
cells into the extracellular space. In the past decade, secretome-based therapies have …
cells into the extracellular space. In the past decade, secretome-based therapies have …
[HTML][HTML] Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine
A González-González, D García-Sánchez… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are the most frequently used stem cells in clinical trials due
to their easy isolation from various adult tissues, their ability of homing to injury sites and …
to their easy isolation from various adult tissues, their ability of homing to injury sites and …