Mast cells and their mediators have been implicated in the pathogenesis of asthma and
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …

Mast cells in tissues are developed from mast cell progenitors emerging from the bone
marrow in a process highly regulated by transcription factors. Through the advancement of …

Mast cells are rare tissue-resident immune cells that are involved in allergic reactions, and
their numbers are increased in the lungs of asthmatics. Murine lung mast cells arise from …

Background Airway hyperresponsiveness (AHR) is a feature of asthma in which airways are
hyperreactive to stimuli causing extensive airway narrowing. Methacholine provocations …

Allergic asthma is a chronic lung disease characterized by airway hyperresponsiveness and
cellular infiltration that is exacerbated by immunoglobulin E-dependent mast cell (MC) …

Following myocardial infarction (MI), resident innate immune cells such as macrophages,
innate lymphoid cells, and mast cells rapidly coordinate their function to contain …

Mast cells (MCs) are tissue resident cells, rich in inflammatory mediators, involved in allergic
reactions, and with an increasingly recognized role in immunomodulation. Dendritic cells …

Mast cells originate from the bone marrow and develop into c-kit+ FcɛRI+ cells. Both mast
cell progenitors (MCp) and mature mast cells express these cell surface markers, and ways …

Mast cells (MCs) are powerful immune cells that mature in the peripheral tissues from bone
marrow (BM)-derived mast cell progenitors (MCp). Accumulation of MCs in lung …

Background Studies using mouse models have revealed that mast cell progenitors are
recruited from the blood circulation to the lung during acute allergic airway inflammation …