The Escherichia coli replication origin oriC contains the initiator ATP-DnaA-Oligomerization
Region (DOR) and its flanking duplex unwinding element (DUE). In the Left-DOR subregion …

This review summarizes current knowledge about the mechanisms of timely binding and
dissociation of two nucleoid proteins, IHF and Fis, which play fundamental roles in the …

Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation
of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed …

The replication of DNA is a complex biological process that is essential for life. Bacterial
DNA replication is initiated at genomic loci referred to as replication origins (oriC s) …

Genome duplication is essential for the proliferation of cellular life and this process is
generally initiated by dedicated replication proteins at chromosome origins. In bacteria, DNA …

Studies of bacterial chromosomes and plasmids indicate that their replication initiator
proteins bind to origins of replication at many double-stranded sites and also at AT-rich …

Genome replication is a fundamental requirement for the proliferation of all cells. Throughout
the domains of life, conserved DNA replication initiation proteins assemble at specific …

Bidirectional DNA replication from a chromosome origin requires the asymmetric loading of
two helicases, one for each replisome. Our understanding of the molecular mechanisms …

oriC is a region of the bacterial chromosome at which the initiator protein DnaA interacts with
specific sequences, leading to DNA unwinding and the initiation of chromosome replication …

Although the mechanism of DNA replication initiation has been investigated for over 50
years, many important discoveries have been made related to this process in recent years …