[HTML][HTML] DNA gyrase inhibitors: Progress and synthesis of potent compounds as antibacterial agents
DNA gyrase is classified as topoisomerase II, an ATP-dependent enzyme that is vital in the
transcription, replication of DNA and chromosome segregation processes. It plays a crucial …
transcription, replication of DNA and chromosome segregation processes. It plays a crucial …
Recent advances in DNA gyrase-targeted antimicrobial agents
Antimicrobial resistance is one of the greatest challenges facing the world today. In the
United States alone, it is responsible for the death of more than 20,000 people each year …
United States alone, it is responsible for the death of more than 20,000 people each year …
An appraisal of anti-mycobacterial activity with structure-activity relationship of piperazine and its analogues: A review
Piperazine, is privileged six membered nitrogen containing heterocyclic ring also known as
1, 4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important …
1, 4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important …
Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1, 2, 4-oxadiazole moiety
TG Shruthi, S Eswaran, P Shivarudraiah… - Bioorganic & medicinal …, 2019 - Elsevier
Tuberculosis is the infectious disease caused by mycobacterium tuberculosis (Mtb),
responsible for the utmost number of deaths annually across the world. Herein, twenty-one …
responsible for the utmost number of deaths annually across the world. Herein, twenty-one …
Mycobacterium Tuberculosis (MTB) GyrB inhibitors: An attractive approach for developing novel drugs against TB
New classes of drugs are needed to treat tuberculosis (TB) in order to combat the
emergence of resistance (MDR and XDR) to existing agents and shorten the duration of …
emergence of resistance (MDR and XDR) to existing agents and shorten the duration of …
Schematic-portfolio of potent anti-microbial scaffolds targeting DNA gyrase: unlocking ways to overcome resistance
K Pakeeraiah, S Mal, M Mahapatra, SK Mekap… - International Journal of …, 2024 - Elsevier
Drug development process demands validation of specific drug target impeding the Multi
Drug Resistance (MDR). DNA gyrase, as a bacterial target has been in trend for developing …
Drug Resistance (MDR). DNA gyrase, as a bacterial target has been in trend for developing …
Piperazine derivatives with potent drug moiety as efficient acetylcholinesterase, butyrylcholinesterase, and glutathione S‐transferase inhibitors
MO Karaytuğ, N Balcı, F Türkan… - … of Biochemical and …, 2023 - Wiley Online Library
Cholinesterases catalyze the breakdown of the neurotransmitter acetylcholine (ACh), a
naturally occurring neurotransmitter, into choline and acetic acid, allowing the nervous …
naturally occurring neurotransmitter, into choline and acetic acid, allowing the nervous …
Targeting DNA replication and repair for the development of novel therapeutics against tuberculosis
Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), an infectious
disease which results in approximately 10 million incident cases and 1.4 million deaths …
disease which results in approximately 10 million incident cases and 1.4 million deaths …
Discovery of 1, 2, 3-triazole incorporated indole-piperazines as potent antitubercular agents: Design, synthesis, in vitro biological evaluation, molecular docking and …
R Reddyrajula, U Etikyala, V Manga… - Bioorganic & Medicinal …, 2024 - Elsevier
In this report, a library consisting of three sets of indole-piperazine derivatives was designed
through the molecular hybridization approach. In total, fifty new hybrid compounds (T1-T50) …
through the molecular hybridization approach. In total, fifty new hybrid compounds (T1-T50) …
Recent advancements in the medicinal chemistry of bacterial type II topoisomerase inhibitors
Replication proteins are sought as a potential targets for antimicrobial agents. Despite their
promising target characteristics, only topoisomerase II inhibitors targeting DNA gyrase …
promising target characteristics, only topoisomerase II inhibitors targeting DNA gyrase …