Background. Growth hormone (GH) and insulin‐like growth factor (IGF‐1) are fundamental
in skeletal growth during puberty and bone health throughout life. GH increases tissue …

Environmental events, both physical and emotional, can produce stress reactions to widely
varying degrees. Stress can affect many aspects of physiology, and levels of stress …

The somatomedin hypothesis proposed that insulin-like growth factor I (IGF-I) was a
hepatically derived circulating mediator of growth hormone and is a crucial factor for …

Since the original somatomedin hypothesis was conceived, a number of important
discoveries have allowed investigators to modify the concept. Originally somatic growth was …

Growth hormone (GH) and its mediator, the insulin-like growth factor-1 (IGF-1) regulate
somatic growth, metabolism and many aspects of aging. As such, actions of GH/IGF have …

Introduction H YPOPHYSECTOMIZED rats have a defect in the synthesis of matrix protein
which is rapidly repaired by the administration of GH in vivo. In 1957, it was first reported that …

Insulin‐like growth factors (IGFs) are essential for growth and survival that suppress
apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in …

Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that
are frequently used to treat inflammatory diseases. Major complications associated with long …

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The body growth of animals is regulated by growth hormone and IGF-I. The classical theory
of this regulation is that most IGF-I in the blood originates in the liver and that body growth is …