Immunometabolism in early and late stages of rheumatoid arthritis

CM Weyand, JJ Goronzy - Nature Reviews Rheumatology, 2017 - nature.com
One of the fundamental traits of immune cells in rheumatoid arthritis (RA) is their ability to
proliferate, a property shared with the joint-resident cells that form the synovial pannus. The …

[HTML][HTML] Metabolomics for the masses: The future of metabolomics in a personalized world

DK Trivedi, KA Hollywood, R Goodacre - New horizons in translational …, 2017 - Elsevier
Current clinical practices focus on a small number of biochemical directly related to the
pathophysiology with patients and thus only describe a very limited metabolome of a patient …

Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism

F Pin, R Barreto, ME Couch, A Bonetto… - Journal of cachexia …, 2019 - Wiley Online Library
Background Cancer cachexia is a metabolic disorder involving perturbed energy balance
and altered mitochondrial function. Chemotherapy is a primary treatment option for many …

GlycA: a composite nuclear magnetic resonance biomarker of systemic inflammation

JD Otvos, I Shalaurova, J Wolak-Dinsmore… - Clinical …, 2015 - academic.oup.com
BACKGROUND Nuclear magnetic resonance (NMR) spectra of serum obtained under
quantitative conditions for lipoprotein particle analyses contain additional signals that could …

The biomarker GlycA is associated with chronic inflammation and predicts long-term risk of severe infection

SC Ritchie, P Würtz, AP Nath, G Abraham… - Cell systems, 2015 - cell.com
The biomarker glycoprotein acetylation (GlycA) has been shown to predict risk of
cardiovascular disease and all-cause mortality. Here, we characterize biological processes …

Metabolomics in rheumatoid arthritis: Advances and review

L Xu, C Chang, P Jiang, K Wei, R Zhang, Y Jin… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease accompanied by metabolic alterations.
The metabolic profiles of patients with RA can be determined using targeted and non …

Functional analysis of colonic bacterial metabolism: relevant to health?

HM Hamer, V De Preter, K Windey… - American Journal of …, 2012 - journals.physiology.org
With the use of molecular techniques, numerous studies have evaluated the composition of
the intestinal microbiota in health and disease. However, it is of major interest to supplement …

Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis

M Souto-Carneiro, L Tóth, R Behnisch… - Annals of the …, 2020 - ard.bmj.com
Objectives The differential diagnosis of seronegative rheumatoid arthritis (negRA) and
psoriasis arthritis (PsA) is often difficult due to the similarity of symptoms and the …

Global metabolite profiling of synovial fluid for the specific diagnosis of rheumatoid arthritis from other inflammatory arthritis

S Kim, J Hwang, J Xuan, YH Jung, HS Cha, KH Kim - PloS one, 2014 - journals.plos.org
Currently, reliable biomarkers that can be used to distinguish rheumatoid arthritis (RA) from
other inflammatory diseases are unavailable. To find possible distinctive metabolic patterns …

The impact of inflammation on metabolomic profiles in patients with arthritis

SP Young, SR Kapoor, MR Viant, JJ Byrne… - Arthritis & …, 2013 - Wiley Online Library
Objective Inflammatory arthritis is associated with systemic manifestations including
alterations in metabolism. We used nuclear magnetic resonance (NMR) spectroscopy …