Inflammation in ALS/FTD pathogenesis

ME McCauley, RH Baloh - Acta neuropathologica, 2019 - Springer
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases that overlap in their clinical presentation, pathology and …

C9ORF72: what it is, what it does, and why it matters

J Smeyers, EG Banchi, M Latouche - Frontiers in cellular …, 2021 - frontiersin.org
When the non-coding repeat expansion in the C9ORF72 gene was discovered to be the
most frequent cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis …

C9orf72 in myeloid cells suppresses STING-induced inflammation

ME McCauley, JG O'Rourke, A Yáñez, JL Markman… - Nature, 2020 - nature.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative disorders that overlap in their clinical presentation, pathology and …

Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis

MD Wang, J Little, J Gomes, NR Cashman, D Krewski - Neurotoxicology, 2017 - Elsevier
Although amyotrophic lateral sclerosis (ALS) was identified as a neurological condition 150
years ago, risk factors related to the onset and progression of ALS remain largely unknown …

Novel functions of the neurodegenerative-related gene tau in cancer

R Gargini, B Segura-Collar… - Frontiers in aging …, 2019 - frontiersin.org
The analysis of global and comparative genomics between different diseases allows us to
understand the key biological processes that explain the etiology of these pathologies. We …

Genome-wide genetic links between amyotrophic lateral sclerosis and autoimmune diseases

CY Li, TM Yang, RW Ou, QQ Wei, HF Shang - BMC medicine, 2021 - Springer
Background Epidemiological and clinical studies have suggested comorbidity between
amyotrophic lateral sclerosis (ALS) and autoimmune disorders. However, little is known …

Emerging evidences for an implication of the neurodegeneration-associated protein tau in cancer

S Papin, P Paganetti - Brain sciences, 2020 - mdpi.com
Neurodegenerative disorders and cancer may appear unrelated illnesses. Yet,
epidemiologic studies indicate an inverse correlation between their respective incidences …

The increasing importance of environmental conditions in amyotrophic lateral sclerosis

J Riancho, P Bosque-Varela, S Perez-Pereda… - International journal of …, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease
affecting motor neurons (MNs). Although a small percentage of ALS has a familial origin, the …

Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: Pathway to discovery of etiology via lifetime exposome research

PS Spencer, VS Palmer, GE Kisby… - Frontiers in …, 2023 - frontiersin.org
The identity and role of environmental factors in the etiology of sporadic amyotrophic lateral
sclerosis (sALS) is poorly understood outside of three former high-incidence foci of Western …

The role of magnetic fields in neurodegenerative diseases

J Riancho, JR Sanchez de la Torre… - International Journal of …, 2021 - Springer
The term neurodegenerative diseases include a long list of diseases affecting the nervous
system that are characterized by the degeneration of different neurological structures …