Cilia and flagella are microtubule-based organelles whose assembly requires a motile
process, known as intraflagellar transport (IFT), to bring tubulin and other components to the …

Many organisms and tissues display the ability to heal and regenerate as needed for normal
physiology and as a result of pathogenesis. However, these repair activities can also be …

The assembly of the axoneme, the structural scaffold of cilia and flagella, requires
translocation of a vast quantity of tubulin into the growing cilium, but the mechanisms that …

Rapid and reductive cell divisions during embryogenesis require that intracellular structures
adapt to a wide range of cell sizes. The mitotic spindle presents a central example of this …

Many primary sensory cilia exhibit unique architectures that are critical for transduction of
specific sensory stimuli. Although basic ciliogenic mechanisms are well described, how …

The mitotic spindle must function in cell types that vary greatly in size, and its dimensions
scale with the rapid, reductive cell divisions that accompany early stages of development …

Background During the assembly and maintenance of cilia, precursor proteins need to be
transported from the cell body into the organelle. Intraflagellar transport (IFT) is assumed to …

Intraflagellar transport (IFT) carries proteins into flagella but how IFT trains interact with the
large number of diverse proteins required to assemble flagella remains largely unknown …

As cells grow, the size and number of their internal organelles increase in order to keep up
with increased metabolic requirements. Abnormal size of organelles is a hallmark of cancer …

The cell represents a highly organized state of living matter in which numerous geometrical
parameters are under dynamic regulation in order to match the form of a cell with its function …