The dark pigment neuromelanin (NM) is abundant in cell bodies of dopamine (DA) neurons
in the substantia nigra (SN) and norepinephrine (NE) neurons in the locus coeruleus (LC) in …

Since the description of some peculiar symptoms by James Parkinson in 1817, attempts
have been made to define its cause or at least to enlighten the pathology of “Parkinson's …

Methamphetamine (METH) produces a cytopathology, which is rather specific within
catecholamine neurons both in vitro and ex vivo, in animal models and chronic METH …

Parkinson's disease is characterized by its distinct pathological features; loss of dopamine
neurons in the substantia nigra pars compacta and accumulation of Lewy bodies and Lewy …

Neuromelanin granules (NMGs) are organelle-like structures present in the human
substantia nigra pars compacta. In addition to neuromelanin, NMGs contain proteins, lipids …

Parkinson's disease is an increasingly prevalent condition that involves the marked loss of
dopaminergic neurons in the substantia nigra pars compacta. These neurons pigmented …

Desmin gene mutations cause myopathies and cardiomyopathies. Our previously
characterised R349P desminopathy mice, which carry the ortholog of the common human …

Background Glucose overload drives diabetic cardiomyopathy by affecting the tricarboxylic
acid pathway. However, it is still unknown how cells could overcome massive chronic …

The present study was performed to examine if catechol oxidation is higher in brains from
patients with Parkinson's disease compared to age-matched controls, and if catechol …

Abstract Multiple System Atrophy (MSA) and Parkinson's diseases (PD) are elite members of
the α-synucleinopathy organization. Aberrant accumulations of the protein α-synuclein …