Capillary transit time (CTT) is a fundamental determinant of gas exchange between blood
and tissues in the heart and other organs. Despite advances in experimental techniques, it …

Cardiac–coronary interaction is fundamental to the function of the heart. As one of the
highest metabolic organs in the body, the cardiac oxygen demand is met by blood perfusion …

Myocardial supply changes to accommodate the variation of myocardial demand across the
heart wall to maintain normal cardiac function. A computational framework that couples the …

Cardiac resynchronization therapy (CRT) is an established treatment for left bundle branch
block (LBBB) resulting in mechanical dyssynchrony. Approximately 1/3 of patients with CRT …

Mechanical dyssynchrony (MD) affects left ventricular (LV) mechanics and coronary
perfusion. To understand the multifactorial effects of MD, we developed a computational …

The mechanisms by which cardiac mechanics effect coronary perfusion (cardiac-to-coronary
coupling) remain incompletely understood. Several coronary models have been proposed to …

Background and objective The myocardial demand-supply feedback system plays an
important role in augmenting blood supply in response to exercise-induced increased …

Sufficient myocardial perfusion plays a pivotal role in maintaining normal pump function.
However the development of a comprehensive myocardial perfusion model remains …

Computational hemodynamics is becoming an increasingly important tool in clinical
applications and surgical procedures involving the cardiovascular system. Aim of this review …

Introduction Prompt reperfusion of coronary artery after acute myocardial infarction (AMI) is
crucial for minimizing heart injury. The myocardium, however, may experience additional …