Heterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that
maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA …

The ribosomal DNA (rDNA) is the most evolutionarily conserved segment of the genome and
gives origin to the nucleolus, an energy intensive nuclear organelle and major hub …

The ribosomal DNA (rDNA) constitutes a remarkably conserved DNA sequence within
species, located in the area of the nucleolus, and responsible for coding three major types of …

The control of non-coding repeated DNA by DNA methylation plays an important role in
genomic stability, contributing to health and healthy aging. Mind-body practices can elicit …

Control of ribosome biogenesis is a critical aspect of the regulation of cell metabolism. As
ribosomal genes (rDNA) are organized in repeated clusters on chromosomes 13, 14, 15, 21 …

Eukaryotes carry hundreds of ribosomal RNA (rRNA) genes as tandem arrays, which
generate rRNA for protein synthesis. Humans carry∼ 400 rRNA gene copies and their …

Borderline personality disorder (BPD) is a serious psychic disease with a high risk for
suicide. DNA methylation is a hallmark for aberrant epigenetic regulation and could be …

A growing amount of evidence suggests that the downregulation of protein synthesis is an
adaptive response during physiological aging, which positively contributes to longevity and …

The alterations of ribosome biogenesis and protein synthesis play a direct role in the
development of tumors. The accessibility and transcription of ribosomal genes is controlled …

Rapid growth and division of cells, including tumor ones, is correlated with intensive protein
biosynthesis. The output of nucleoli, organelles where translational machineries are formed …