The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …
The mammalian ULK1 complex and autophagy initiation
Autophagy is a vital lysosomal degradation pathway that serves as a quality control
mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to …
mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
[HTML][HTML] A molecular perspective of mammalian autophagosome biogenesis
TJ Mercer, A Gubas, SA Tooze - Journal of biological chemistry, 2018 - ASBMB
Autophagy is a highly conserved process and is essential for the maintenance of cellular
homeostasis. Autophagy occurs at a basal level in all cells, but it can be up-regulated during …
homeostasis. Autophagy occurs at a basal level in all cells, but it can be up-regulated during …
[HTML][HTML] Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications
L Zou, M Liao, Y Zhen, S Zhu, X Chen, J Zhang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …
Intracellular hyaluronan: Importance for cellular functions
SS Skandalis, T Karalis, P Heldin - Seminars in cancer biology, 2020 - Elsevier
Hyaluronan-rich matrices are abundant in ECM and are involved in biological processes,
such as cell growth and migration. Hyaluronan is synthesized by the hyaluronan synthase …
such as cell growth and migration. Hyaluronan is synthesized by the hyaluronan synthase …
[HTML][HTML] Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery
Cellular homeostasis relies on both the chaperoning of proteins and the intracellular
degradation system that delivers cytoplasmic constituents to the lysosome, a process known …
degradation system that delivers cytoplasmic constituents to the lysosome, a process known …
[HTML][HTML] Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation
AB Bachman, D Keramisanou, W Xu, K Beebe… - Nature …, 2018 - nature.com
During the Hsp90-mediated chaperoning of protein kinases, the core components of the
machinery, Hsp90 and the cochaperone Cdc37, recycle between different phosphorylation …
machinery, Hsp90 and the cochaperone Cdc37, recycle between different phosphorylation …
Function and regulation of ULK1: From physiology to pathology
Z Rong, K Zheng, J Chen, X Jin - Gene, 2022 - Elsevier
The expression of ULK1, a core protein of autophagy, is closely related to autophagic
activity. Numerous studies have shown that pathological abnormal expression of ULK1 is …
activity. Numerous studies have shown that pathological abnormal expression of ULK1 is …