Heterogeneity describes the differences among cancer cells within and between tumors. It
refers to cancer cells describing variations in morphology, transcriptional profiles …

Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides
regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the …

Genetically identical cells are known to differ in many physiological parameters such as
growth rate and drug tolerance. Metabolic specialization is believed to be a cause of such …

Phenotypic (non-genetic) heterogeneity has significant implications for the development and
evolution of organs, organisms, and populations. Recent observations in multiple cancers …

Highlights•Phenotypic heterogeneity in metabolism is driven by nutrient limitation.•Nutrient
limitation underpins metabolic heterogeneity caused by temporal fluctuations in substrate …

The structure of the metabolic network is highly conserved, but we know little about its
evolutionary origins. Key for explaining the early evolution of metabolism is solving a …

Mutations provide the raw material for natural selection to act. Therefore, understanding the
variety and relative frequency of different type of mutations is critical to understanding the …

The evolutionary transition from single-celled to multicellular growth is a classic and
intriguing problem in biology. Saccharomyces cerevisiae is a useful model to study …

Heterogeneity among isogenic cells/individuals has been known for at least 150 years. Even
Mendel, working on pea plants, realized that not all tall plants were identical. However …

The mechanisms that regulate the balance between stem cell duplication and differentiation
in adult tissues remain in debate. Using a combination of genetic lineage tracing and marker …