MR elastography allows non-invasive quantification of the shear modulus of tissue, ie tissue
stiffness and viscosity, information that offers the potential to guide presurgical planning for …

The mechanical traits of cancer include abnormally high solid stress as well as drastic and
spatially heterogeneous changes in intrinsic mechanical tissue properties. Whereas solid …

Purpose: The tumor microenvironment presents with altered extracellular matrix (ECM) and
stroma composition, which may affect treatment efficacy and contribute to tissue stiffness …

Unlike many other cancer cells that grow in tumors characterized by an abnormally stiff
collagen-enriched stroma, glioma cells proliferate and migrate in the much softer …

Increased stiffness in the extracellular matrix (ECM) contributes to tumor progression and
metastasis. Therefore, stromal modulating therapies and accompanying biomarkers are …

Magnetic resonance elastography holds promise as a non-invasive, easy-to-use, in vivo
biomarker for neurodegenerative diseases. Throughout the past decade, pigs have gained …

This study proposes a computational method for estimating in vivo mechanical properties of
tissues using clinical imaging data. In particular, a new level-set-based objective functional …

Glioblastoma is the most common and aggressive primary malignant brain tumor with poor
prognosis. Novel immunotherapeutic approaches are currently under investigation. Even …

Mechanical stress and fluid flow influence glioma cell phenotype in vitro, but measuring
these quantities in vivo continues to be challenging. The purpose of this study was to predict …

Glioblastoma (GBM) is the most common primary brain tumor. It is highly malignant and has
a correspondingly poor prognosis. Diagnosis and monitoring are mainly accomplished with …