Calprotectin (CLP) is a heterodimer formed by two S-100 calcium-binding cytosolic proteins,
S100A8 and S100A9. It is a multifunctional protein expressed mainly by neutrophils and …

Antigenic stimulation promotes T cell metabolic reprogramming to meet increased
biosynthetic, bioenergetic, and signaling demands. We show that the one-carbon (1C) …

Asthma is a generalized term that describes a scope of distinct pathologic phenotypes of
variable severity, which share a common complication of reversible airflow obstruction …

Women have higher prevalence of asthma compared with men. In asthma, allergic airway
inflammation is initiated by IL-33 signaling through ST2, leading to increased IL-4, IL-5, and …

Background Excessive inflammation has been implicated in the immunopathogenesis of
coronavirus disease 2019 (COVID-19). In the current study, the involvement of S100 calcium …

Functional enrichment analysis of genome-wide association study (GWAS)-summary
statistics has suggested that CD4+ T-cells play an important role in asthma pathogenesis …

Abstract S100A8 and S100A9 are important proteins in the pathogenesis of allergy. Asthma
is an allergic lung disease, characterized by bronchial inflammation due to leukocytes …

S100 calcium-binding protein A9 (S100A9) is elevated in plasma and bronchoalveolar
lavage fluid (BALF) of patients with chronic obstructive pulmonary disease (COPD), and …

The S100 protein family consists of over 20 members in humans that are involved in many
intracellular and extracellular processes, including proliferation, differentiation, apoptosis …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease in which most
patients die within 3 years of diagnosis. With an unknown etiology, IPF results in progressive …