The zebrafish (Danio rerio) is rapidly becoming a popular model organism in
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

The development of new treatments for substance use disorders requires identification of
targetable molecular mechanisms. Pathology in glutamatergic neurotransmission system in …

Publisher Summary The chapter discusses ibogaine, which is a naturally occurring plant
alkaloid with a history of use as a medicinal and ceremonial agent in West Central Africa …

Basic research concerning drug tolerance and withdrawal may inform clinical practice, and
vice versa. Three areas that integrate the work of the laboratory and the clinic are …

The pharmacological effects of ethanol are complex and widespread without a well-defined
target. Since glutamatergic and GABAergic innervation are both dense and diffuse and …

Rationale: Preclinical observations suggest that NMDA receptor-mediated glutamatergic
neurotransmission is involved in the expression and maintenance of opioid dependence …

Recent data points to glutamatergic dysfunction in mood disorders, anxiety disorders,
obsessive–compulsive disorder, and schizophrenia. Memantine, a drug approved by the …

In the present study we examined the effect of MPEP [2-methyl-6-(phenylethynyl)-pyridine] a
potent, selective and systemically active metabotropic glutamate receptor (mGluR) type I …

There is evidence from in vitro and in vivo studies that homocysteine induces neuronal
damage and cell loss by both excitotoxicity and different apoptotic processes. Clinical …