Dabigatran-metabolism, pharmacologic properties and drug interactions
NM Antonijevic, ID Zivkovic… - Current drug …, 2017 - ingentaconnect.com
Background: The superiority of dabigatran has been well proven in the standard dosing
regimen in prevention of stroke and systemic embolism in patients with non-valvular atrial …
regimen in prevention of stroke and systemic embolism in patients with non-valvular atrial …
Potential drug–drug interactions with direct oral anticoagulants in elderly hospitalized patients
HL Forbes, TM Polasek - Therapeutic advances in drug …, 2017 - journals.sagepub.com
Background: To determine the prevalence and nature of potential drug–drug interactions
(DDIs) with direct oral anticoagulants (DOACs) in elderly hospitalized patients. Methods …
(DDIs) with direct oral anticoagulants (DOACs) in elderly hospitalized patients. Methods …
A proposal for dose‐adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time
PKL Chin, DFB Wright, DM Patterson… - British journal of …, 2014 - Wiley Online Library
Dabigatran is an oral anticoagulant that is increasingly used for atrial fibrillation (AF).
Presently, many authorities state that routine laboratory coagulation monitoring is not …
Presently, many authorities state that routine laboratory coagulation monitoring is not …
Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C
PKL Chin, DFB Wright, M Zhang, MC Wallace… - Drugs in R&D, 2014 - Springer
Aims Dabigatran is largely cleared by renal excretion. Renal function is thus a major
determinant of trough dabigatran concentrations, which correlate with the risk of …
determinant of trough dabigatran concentrations, which correlate with the risk of …
[HTML][HTML] Evaluation of dabigatran for appropriateness of use and bleeding events in a community hospital setting
AL Armbruster, KS Buehler, SH Min… - American health & …, 2014 - ncbi.nlm.nih.gov
Background Warfarin has been the predominant anticoagulant for the prevention of stroke
and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF). Its …
and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF). Its …
Evaluation of the chromogenic anti-factor IIa assay to assess dabigatran exposure in geriatric patients with atrial fibrillation in an outpatient setting
L Brunetti, B Sanchez-Catanese, L Kagan, X Wen… - Thrombosis journal, 2016 - Springer
Background Dabigatran etexilate may be underutilized in geriatric patients because of
inadequate clinical experience in individuals with severe renal impairment and post …
inadequate clinical experience in individuals with severe renal impairment and post …
Dabigatran for stroke prevention in nonvalvular atrial fibrillation: focus in the geriatric population
L Brunetti, C Chen, J White - The Consultant Pharmacist®, 2014 - ingentaconnect.com
Objective: To evaluate the safety and efficacy of dabigatran for stroke prevention in the
elderly population. Data Sources: MEDLINE (1948-June 2013), Web of Science (1980-June …
elderly population. Data Sources: MEDLINE (1948-June 2013), Web of Science (1980-June …
The challenges and limitations of widespread direct oral anticoagulant treatment: practical suggestions for their best use
G Palareti, D Poli - Expert Review of Cardiovascular Therapy, 2016 - Taylor & Francis
For many decades vitamin K antagonists (VKA), whilst extremely effective but associated
with significant drawbacks, were the only drugs available for chronic anticoagulation …
with significant drawbacks, were the only drugs available for chronic anticoagulation …
Real-world analysis of potential pharmacokinetic and pharmacodynamic drug interactions with apixaban in patients with non-valvular atrial fibrillation
Purpose We conducted this study to assess the real-world prevalence, nature, predictors,
and clinical necessity of apixaban pharmacokinetic (PK) and pharmacodynamic (PD) drug …
and clinical necessity of apixaban pharmacokinetic (PK) and pharmacodynamic (PD) drug …
[HTML][HTML] Prescribing of direct oral anticoagulants in atrial fibrillation based on estimation of renal function using standard and modified Cockcroft–Gault equations: a …
M Kucey, J Bolt, L Albers, A Bell, N Iroh… - The Canadian Journal …, 2016 - ncbi.nlm.nih.gov
Atrial fibrillation affects about 350 000 Canadians. 1 A devastating complication of this
condition is stroke or systemic embolism, the risk of which is 3 to 5 times greater among …
condition is stroke or systemic embolism, the risk of which is 3 to 5 times greater among …