Protein aggregation and neurodegenerative diseases: From theory to therapy
The study of protein misfolding and aggregation saw resurgence in the last decade.
Aggregation is the main cause of several human neurodegenerative diseases which makes …
Aggregation is the main cause of several human neurodegenerative diseases which makes …
A review on protein misfolding, aggregation and strategies to prevent related ailments
This review aims to highlight the fundamental mechanism of protein misfolding leading to
protein aggregation and associated diseases. It also aims to anticipate novel therapeutic …
protein aggregation and associated diseases. It also aims to anticipate novel therapeutic …
Functional implications of pH-induced conformational changes in the Sphingosine kinase 1
Abstract Sphingosine kinase 1 (SphK1) catalyzes the conversion of sphingosine to
sphingosine-1-phosphate that acts as a bioactive signalling molecule, and regulates various …
sphingosine-1-phosphate that acts as a bioactive signalling molecule, and regulates various …
Chitinase from Thermomyces lanuginosus SSBP and its biotechnological applications
Chitinases are ubiquitous class of extracellular enzymes, which have gained attention in the
past few years due to their wide biotechnological applications. The effectiveness of …
past few years due to their wide biotechnological applications. The effectiveness of …
Structural characterization of MG and pre-MG states of proteins by MD simulations, NMR, and other techniques
Almost all proteins fold via a number of partially structured intermediates such as molten
globule (MG) and pre-molten globule states. Understanding the structure of these …
globule (MG) and pre-molten globule states. Understanding the structure of these …
Protein folding: Molecular dynamics simulations and in vitro studies for probing mechanism of urea-and guanidinium chloride-induced unfolding of horse cytochrome …
Urea-and guanidinium chloride (GdmCl)-induced denatured states of horse cytochrome-c
(cyt-c) are structurally identical. It is then expected that estimates of∆ G 0 N→ U (Gibbs free …
(cyt-c) are structurally identical. It is then expected that estimates of∆ G 0 N→ U (Gibbs free …
Mechanistic insights into the urea-induced denaturation of kinase domain of human integrin linked kinase
Abstract Integrin-linked kinase (ILK), a ubiquitously expressed intracellular Ser/Thr protein
kinase, plays a major role in the oncogenesis and tumour progression. The conformational …
kinase, plays a major role in the oncogenesis and tumour progression. The conformational …
Mechanistic insights into the urea-induced denaturation of human sphingosine kinase 1
Abstract Sphingosine kinase 1 (SphK1) plays a significant role in various cellular processes,
including cell proliferation, apoptosis, and angiogenesis. SphK1 is considered as an …
including cell proliferation, apoptosis, and angiogenesis. SphK1 is considered as an …
Effect of pH on structure, function, and stability of mitochondrial carbonic anhydrase VA
Mitochondrial carbonic anhydrase VA (CAVA) catalyzes the hydration of carbon dioxide to
produce proton and bicarbonate which is primarily expressed in the mitochondrial matrix of …
produce proton and bicarbonate which is primarily expressed in the mitochondrial matrix of …
Design and synthesis of a novel class of carbonic anhydrase-IX inhibitor 1-(3-(phenyl/4-fluorophenyl)-7-imino-3H-[1, 2, 3] triazolo [4, 5d] pyrimidin 6 (7H) yl) urea
Carbonic anhydrase IX (CAIX) is a promising target in cancer therapy especially in the case
of hypoxia-induced tumors. The selective inhibition of CA isozymes is a challenging task in …
of hypoxia-induced tumors. The selective inhibition of CA isozymes is a challenging task in …