A variety of cell types in pulmonary arteries (endothelial cells, fibroblasts, and smooth
muscle cells) are continuously exposed to mechanical stimulations such as shear stress and …

Pulmonary hypertension (PH) is a severe and multifactorial disease characterized by a
progressive elevation of pulmonary arterial resistance and pressure due to remodeling …

Key points• A prolonged reduced oxygen level in the lungs, as occurs in patients of many
chronic lung diseases and in residents living at high altitude, causes pulmonary …

Multidrug resistance–associated protein 4 (MRP4, also known as Abcc4) regulates
intracellular levels of cAMP and cGMP in arterial SMCs. Here, we report our studies of the …

Three pairs of undescribed diarylpentanoid enantiomers (1–3) and five undescribed
phenylpropanoids (4–8), along with seven known compounds, were isolated from the roots …

Smooth muscles are widely distributed in mammal body through various systems such as
circulatory, respiratory, gastro-intestinal and urogenital systems. The smooth muscle cell …

In smooth muscle cells, agonists such as neurotransmitters or hormones can induce an
increase in [Ca2+] i via a release of intracellular stored calcium or/and an influx of …

Background Endothelial control of vascular smooth muscle plays a major role in the
resulting vasoreactivity implicated in physiological or pathological circulatory processes …

Pulmonary arterial hypertension (PAH) is a serious pathological phenomenon with poor
prognosis, which is associated with morphological as well as hemodynamic alteration of the …

There is a growing body of evidence indicating that transient receptor potential (TRP)
channels are implicated in calcium signaling and various cellular functions in the pulmonary …