Recent developments in ruthenium anticancer drugs
Interest in Ru anticancer drugs has been growing rapidly since NAMI-A ((ImH+)[RuIIICl4
(Im)(S-dmso)], where Im= imidazole and S-dmso= S-bound dimethylsulfoxide) or KP1019 …
(Im)(S-dmso)], where Im= imidazole and S-dmso= S-bound dimethylsulfoxide) or KP1019 …
In situ imaging of metals in cells and tissues
R McRae, P Bagchi, S Sumalekshmy… - Chemical …, 2009 - ACS Publications
Approximately one third of the human proteome contains metal cations, either in the form of
cofactors with catalytic functions or as structural support elements. 1, 2 To guarantee a …
cofactors with catalytic functions or as structural support elements. 1, 2 To guarantee a …
Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities
Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …
animal cells is a widespread area of research, yet little is known about the reactivity and …
The bioinorganic chemistry of chromium (III)
JB Vincent - Polyhedron, 2001 - Elsevier
The biochemistry of chromium (III) has been a poorly understood field of endeavor. Despite
four decades of investigation, only recently has a somewhat clear picture of the role of Cr …
four decades of investigation, only recently has a somewhat clear picture of the role of Cr …
Chemical properties and toxicity of chromium (III) nutritional supplements
The status of Cr (III) as an essential micronutrient for humans is currently under question. No
functional Cr (III)-containing biomolecules have been definitively described as yet, and …
functional Cr (III)-containing biomolecules have been definitively described as yet, and …
Fluorescent, phosphorescent, magnetic resonance contrast and radioactive tracer labelling of extracellular vesicles
This review focusses on the significance of fluorescent, phosphorescent labelling and
tracking of extracellular vesicles (EVs) for unravelling their biology, pathophysiology, and …
tracking of extracellular vesicles (EVs) for unravelling their biology, pathophysiology, and …
X-ray-induced photo-chemistry and X-ray absorption spectroscopy of biological samples
As synchrotron light sources and optics deliver greater photon flux on samples, X-ray-
induced photo-chemistry is increasingly encountered in X-ray absorption spectroscopy …
induced photo-chemistry is increasingly encountered in X-ray absorption spectroscopy …
Metal-based anti-diabetic drugs: advances and challenges
The current status and likely future directions of complexes of V (V/IV), Cr (III), Mo (VI), W (VI),
Zn (II), Cu (II), and Mn (III) as potential oral drugs against type 2 diabetes are reviewed. We …
Zn (II), Cu (II), and Mn (III) as potential oral drugs against type 2 diabetes are reviewed. We …
Characterization of a ruthenium (III)/NAMI‐A adduct with bovine serum albumin that exhibits a high anti‐metastatic activity
M Liu, ZJ Lim, YY Gwee, A Levina… - Angewandte Chemie …, 2010 - Wiley Online Library
Interest in ruthenium-based anti-metastatic drugs with low cytotoxicity is rapidly growing,[1–
3] for example, NAMI-A (1, Figure 1)[2] has completed phase I clinical trials.[4] Although its …
3] for example, NAMI-A (1, Figure 1)[2] has completed phase I clinical trials.[4] Although its …
Reactivity and speciation of anti-diabetic vanadium complexes in whole blood and its components: The important role of red blood cells
A Levina, AI McLeod, SJ Gasparini, A Nguyen… - Inorganic …, 2015 - ACS Publications
Reactions with blood components are crucial for controlling the antidiabetic, anticancer, and
other biological activities of V (V) and V (IV) complexes. Despite extensive studies of V (V) …
other biological activities of V (V) and V (IV) complexes. Despite extensive studies of V (V) …