Recent developments in ruthenium anticancer drugs

A Levina, A Mitra, PA Lay - Metallomics, 2009 - academic.oup.com
Interest in Ru anticancer drugs has been growing rapidly since NAMI-A ((ImH+)[RuIIICl4
(Im)(S-dmso)], where Im= imidazole and S-dmso= S-bound dimethylsulfoxide) or KP1019 …

In situ imaging of metals in cells and tissues

R McRae, P Bagchi, S Sumalekshmy… - Chemical …, 2009 - ACS Publications
Approximately one third of the human proteome contains metal cations, either in the form of
cofactors with catalytic functions or as structural support elements. 1, 2 To guarantee a …

Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities

A Levina, DC Crans, PA Lay - Coordination Chemistry Reviews, 2017 - Elsevier
Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …

The bioinorganic chemistry of chromium (III)

JB Vincent - Polyhedron, 2001 - Elsevier
The biochemistry of chromium (III) has been a poorly understood field of endeavor. Despite
four decades of investigation, only recently has a somewhat clear picture of the role of Cr …

Chemical properties and toxicity of chromium (III) nutritional supplements

A Levina, PA Lay - Chemical research in toxicology, 2008 - ACS Publications
The status of Cr (III) as an essential micronutrient for humans is currently under question. No
functional Cr (III)-containing biomolecules have been definitively described as yet, and …

Fluorescent, phosphorescent, magnetic resonance contrast and radioactive tracer labelling of extracellular vesicles

K Wardhani, A Levina, GER Grau, PA Lay - Chemical Society Reviews, 2024 - pubs.rsc.org
This review focusses on the significance of fluorescent, phosphorescent labelling and
tracking of extracellular vesicles (EVs) for unravelling their biology, pathophysiology, and …

X-ray-induced photo-chemistry and X-ray absorption spectroscopy of biological samples

GN George, IJ Pickering, MJ Pushie… - Journal of …, 2012 - journals.iucr.org
As synchrotron light sources and optics deliver greater photon flux on samples, X-ray-
induced photo-chemistry is increasingly encountered in X-ray absorption spectroscopy …

Metal-based anti-diabetic drugs: advances and challenges

A Levina, PA Lay - Dalton transactions, 2011 - pubs.rsc.org
The current status and likely future directions of complexes of V (V/IV), Cr (III), Mo (VI), W (VI),
Zn (II), Cu (II), and Mn (III) as potential oral drugs against type 2 diabetes are reviewed. We …

Characterization of a ruthenium (III)/NAMI‐A adduct with bovine serum albumin that exhibits a high anti‐metastatic activity

M Liu, ZJ Lim, YY Gwee, A Levina… - Angewandte Chemie …, 2010 - Wiley Online Library
Interest in ruthenium-based anti-metastatic drugs with low cytotoxicity is rapidly growing,[1–
3] for example, NAMI-A (1, Figure 1)[2] has completed phase I clinical trials.[4] Although its …

Reactivity and speciation of anti-diabetic vanadium complexes in whole blood and its components: The important role of red blood cells

A Levina, AI McLeod, SJ Gasparini, A Nguyen… - Inorganic …, 2015 - ACS Publications
Reactions with blood components are crucial for controlling the antidiabetic, anticancer, and
other biological activities of V (V) and V (IV) complexes. Despite extensive studies of V (V) …