[HTML][HTML] Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies
There is an increasing momentum in research and pharmaceutical industry communities to
design sustained, non-invasive delivery systems to treat chronic neovascular ocular …
design sustained, non-invasive delivery systems to treat chronic neovascular ocular …
Sustained release glaucoma therapies: Novel modalities for overcoming key treatment barriers associated with topical medications
Glaucoma is a progressive optic neuropathy and a leading cause of irreversible blindness.
The disease has conventionally been characterized by an elevated intraocular pressure …
The disease has conventionally been characterized by an elevated intraocular pressure …
Recent advances of ocular drug delivery systems: prominence of ocular implants for chronic eye diseases
Chronic ocular diseases can seriously impact the eyes and could potentially result in
blindness or serious vision loss. According to the most recent data from the WHO, there are …
blindness or serious vision loss. According to the most recent data from the WHO, there are …
[HTML][HTML] Microparticles and multi-unit systems for advanced drug delivery
Microparticles have unique benefits in the formulation of multiparticulate and multi-unit type
pharmaceutical dosage forms allowing improved drug safety and efficacy with favorable …
pharmaceutical dosage forms allowing improved drug safety and efficacy with favorable …
[HTML][HTML] Restoring the oxidative balance in age-related diseases–An approach in glaucoma
As human life expectancy increases, age-related health issues including neurodegenerative
diseases continue to rise. Regardless of genetic or environmental factors, many …
diseases continue to rise. Regardless of genetic or environmental factors, many …
Rho-kinase inhibitors as emerging targets for glaucoma therapy
J Wang, H Wang, Y Dang - Ophthalmology and Therapy, 2023 - Springer
Glaucoma, the leading cause of irreversible blindness worldwide, is a chronic and
progressive optic neuropathy characterized by damage to the optic and retinal nerve fiber …
progressive optic neuropathy characterized by damage to the optic and retinal nerve fiber …
Rho-kinase inhibitors for the treatment of refractory diabetic macular oedema
M Mateos-Olivares, L García-Onrubia… - Cells, 2021 - mdpi.com
Diabetic macular oedema (DMO) is one of the leading causes of vision loss associated with
diabetic retinopathy (DR). New insights in managing this condition have changed the …
diabetic retinopathy (DR). New insights in managing this condition have changed the …
Encapsulation of large-size plasmids in PLGA nanoparticles for gene editing: comparison of three different synthesis methods
The development of new gene-editing technologies has fostered the need for efficient and
safe vectors capable of encapsulating large nucleic acids. In this work we evaluate the …
safe vectors capable of encapsulating large nucleic acids. In this work we evaluate the …
Exploring the Ocular Absorption Pathway of Fasudil Hydrochloride towards Developing a Nanoparticulate Formulation with Improved Performance
Rho-kinase (ROCK) inhibitors represent a new category of anti-glaucoma medications.
Among them, Fasudil hydrochloride, a selective ROCK inhibitor, has demonstrated …
Among them, Fasudil hydrochloride, a selective ROCK inhibitor, has demonstrated …
The Role of Rho Kinase Inhibitors in Corneal Diseases
S Futterknecht, E Chatzimichail, K Gugleta… - Drug Design …, 2024 - Taylor & Francis
The cornea, as the outermost layer of the eye, plays a crucial role in vision by focusing light
onto the retina. Various diseases and injuries can compromise its clarity, leading to impaired …
onto the retina. Various diseases and injuries can compromise its clarity, leading to impaired …