Astrocyte calcium signaling: the third wave

N Bazargani, D Attwell - Nature neuroscience, 2016 - nature.com
The discovery that transient elevations of calcium concentration occur in astrocytes, and
release'gliotransmitters' which act on neurons and vascular smooth muscle, led to the idea …

Gliotransmitters travel in time and space

A Araque, G Carmignoto, PG Haydon, SHR Oliet… - Neuron, 2014 - cell.com
The identification of the presence of active signaling between astrocytes and neurons in a
process termed gliotransmission has caused a paradigm shift in our thinking about brain …

Three-dimensional Ca2+ imaging advances understanding of astrocyte biology

E Bindocci, I Savtchouk, N Liaudet, D Becker… - Science, 2017 - science.org
INTRODUCTION Astrocytes translate incoming information and generate functional outputs
via Ca2+ signaling. Thereby, they respond to neuronal activity, producing downstream …

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

A Mishra, JP Reynolds, Y Chen, AV Gourine… - Nature …, 2016 - nature.com
Active neurons increase their energy supply by dilating nearby arterioles and capillaries.
This neurovascular coupling underlies blood oxygen level–dependent functional imaging …

Coupling mechanism and significance of the BOLD signal: a status report

EMC Hillman - Annual review of neuroscience, 2014 - annualreviews.org
Functional magnetic resonance imaging (fMRI) provides a unique view of the working
human mind. The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects …

Glial and neuronal control of brain blood flow

D Attwell, AM Buchan, S Charpak, M Lauritzen… - Nature, 2010 - nature.com
Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these
cells control blood flow is crucial for understanding how neural computation is powered, for …

Glia as sculptors of synaptic plasticity

L Sancho, M Contreras, NJ Allen - Neuroscience Research, 2021 - Elsevier
Glial cells are non-neuronal cells in the nervous system that are crucial for proper brain
development and function. Three major classes of glia in the central nervous system (CNS) …

Astrocyte regulation of blood flow in the brain

BA MacVicar, EA Newman - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Neuronal activity results in increased blood flow in the brain, a response named functional
hyperemia. Astrocytes play an important role in mediating this response. Neurotransmitters …

Adult neurogenesis, glia, and the extracellular matrix

EC Cope, E Gould - Cell Stem Cell, 2019 - cell.com
In the adult mammalian hippocampus, new neurons arise from stem and progenitor cell
division, in a process known as adult neurogenesis. Adult-generated neurons are sensitive …

Cortical circuit activity evokes rapid astrocyte calcium signals on a similar timescale to neurons

JL Stobart, KD Ferrari, MJP Barrett, C Glück, MJ Stobart… - Neuron, 2018 - cell.com
Sensory stimulation evokes intracellular calcium signals in astrocytes; however, the timing of
these signals is disputed. Here, we used novel combinations of genetically encoded calcium …