Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in
metazoans and cyclic AMP in Dictyostelium, activate signaling pathways that control …

Rho GTPases control signal transduction pathways that link cell surface receptors to a
variety of intracellular responses. They are best known as regulators of the actin …

Loss of function of the PTEN tumour suppressor, resulting in dysregulated activation of the
phosphoinositide 3-kinase (PI3K) signalling network, is recognized as one of the most …

In eukaryotic cells directional sensing is mediated by heterotrimeric guanine nucleotide–
binding protein (G protein)–linked signaling pathways. In Dictyostelium discoideum …

Dictyostelia are soil amoebae capable of extraordinary feats of survival, motility, chemotaxis,
and development. Characterised by their ability to transform from a single-celled organism …

Chemotaxis, the directed migration of cells in chemical gradients, is a vital process in normal
physiology and in the pathogenesis of many diseases. Chemotactic cells display motility …

During random locomotion, human neutrophils and Dictyostelium discoideum amoebae
repeatedly extend and retract cytoplasmic processes. During directed cell migration …