Uromodulin (Tamm–Horsfall protein) is the most abundant protein excreted in the urine
under physiological conditions. It is exclusively produced in the kidney and secreted into the …

▪ Abstract Many eukaryotic proteins share a sequence designated as the zona pellucida (ZP)
domain. This structural element, present in extracellular proteins from a wide variety of …

Successful fertilization heralds the onset of development and requires both gamete
recognition and a definitive block to polyspermy. Sperm initially bind and penetrate the …

All mammalian eggs are surrounded by a relatively thick extracellular coat, the zona
pellucida, that plays vital roles during oogenesis, fertilization, and preimplantation …

The zona pellucida (ZP) is an extracellular matrix that surrounds all mammalian oocytes,
eggs, and early embryos and plays vital roles during oogenesis, fertilization, and …

Cholesterol provided by low-or high-density lipoprotein is the precursor for biosynthesis of
progesterone. Once inside the cell, cholesterol can be used for steroidogenesis or esterified …

Fertility in female mammals, including mice and humans, is dependent on the presence of a
zona pellucida (ZP) around growing oocytes and unfertilized eggs. A ZP is required to …

Purpose The oocyte-borne genetic causes leading to fertilization failure are largely
unknown. We aimed to identify novel human pathogenic variants (PV) and genes causing …

Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal
epithelial cells and it plays key roles in kidney function and disease. Uromodulin mainly …

Zona pellucida (ZP) is a glycoproteinaceous translucent matrix that surrounds the
mammalian oocyte and plays a critical role in the accomplishment of fertilization. In humans …