The ability to continuously monitor the concentration of specific molecules in the body is a
long-sought goal of biomedical research. For this purpose, interstitial fluid (ISF) was …

Antimicrobial resistance is a major global health challenge. As few new efficacious
antibiotics will become available in the near future, peptide antibiotics continue to be major …

The revised vancomycin guidelines recommend implementing AUC24-based therapeutic
drug monitoring (TDM) using Bayesian methods in both adults and paediatrics. The …

The measurement of serum vancomycin levels at the clinic is critical to optimizing dosing
given the narrow therapeutic window of this antibiotic. Current approaches to quantitate …

Background Evidence supports therapeutic drug monitoring of polymyxin B, but clinical data
for establishing an area under the concentration–time curve across 24 h at steady state …

Vancomycin was introduced nearly 65 years ago and remains the standard antibiotic for
serious methicillin-resistant Staphylococcus aureus (MRSA) infections. Staphylococcus …

In this counterpoint we critically appraise the evidence supporting therapeutic drug
monitoring based on the vancomycin 24-hour area under the concentration-time curve …

Background Staphylococcus aureus bloodstream infections are common and associated
with a high mortality of 15–25%. Methicillin-resistant S. aureus (MRSA) bloodstream …

Background This study compared dalbavancin with standard of care (SOC) for patients with
Staphylococcus aureus bacteraemia (SAB) who were unable to receive outpatient …

The recently released revised vancomycin consensus guideline endorsed area under the
concentration‐time curve (AUC) guided monitoring. Means to AUC‐guided monitoring …